Barber H R
Department of Obstetrics and Gynecology, Lenox Hill Hospital, New York City, NY 10021.
J Pediatr Surg. 1988 Oct;23(10):967-72. doi: 10.1016/s0022-3468(88)80396-8.
The ovaries and testes have very similar development patterns until about the fourth month of embryonic life. A review of the similar development (until the fourth month) provides an explanation for the origin of tumors commonly associated with ovarian tissue appearing in the testis and vice versa. Embryonic surface epithelium gives rise to mesothelial tissue from which the common epithelial tumors arise in the ovary. Since these cells disappear from the testis when the tunica albuginea develops, this offers an explanation for the lack of common epithelial tumors in the testis. The embryonic gonadal tissue or sex cord epithelium and the primitive germ cells give rise to similar tumors in both the ovary and the testis. The extraembryonal tumors arise from the extraembryonal cells and trophoblastic cells, which give rise to the endodermal sinus tumors and choriocarcinomas, respectively. Since there is such a similarity in the development of the ovary and testis with the potential for residual cells to remain, an explanation is offered for the development of similar tumors in the ovary and the testis.
直到胚胎生命的第四个月左右，卵巢和睾丸的发育模式都非常相似。回顾这种相似的发育过程（直到第四个月），可以解释为何睾丸中会出现通常与卵巢组织相关的肿瘤，反之亦然。胚胎表面上皮产生间皮组织，卵巢中常见的上皮性肿瘤即起源于此。由于当白膜形成时这些细胞从睾丸中消失，这就解释了为何睾丸中缺乏常见的上皮性肿瘤。胚胎性腺组织或性索上皮以及原始生殖细胞在卵巢和睾丸中都会产生相似的肿瘤。胚外肿瘤起源于胚外细胞和滋养层细胞，它们分别产生内胚窦瘤和绒毛膜癌。由于卵巢和睾丸的发育存在如此相似性，且有可能残留细胞，这就为卵巢和睾丸中相似肿瘤的发生提供了解释。
