Department of Orthopaedic Surgery, Singapore General Hospital, Singapore.
Health Service Research Unit, Singapore General Hospital, Singapore.
Bone Joint J. 2019 Feb;101-B(2):213-220. doi: 10.1302/0301-620X.101B2.BJJ-2018-0969.R2.
The aim of this study was to assess the influence of obesity on the clinical outcomes and survivorship ten years postoperatively in patients who underwent a fixed-bearing unicompartmental knee arthroplasty (UKA).
We prospectively followed 184 patients who underwent UKA between 2003 and 2007 for a minimum of ten years. A total of 142 patients with preoperative body mass index (BMI) of < 30 kg/m were in the control group (32 male, 110 female) and 42 patients with BMI of ≥ 30 kg/m were in the obese group (five male, 37 female). Pre- and postoperative range of movement (ROM), Knee Society Score (KSS), Oxford Knee Score (OKS), 36-Item Short-Form Health Survey (SF-36), and survivorship were analyzed.
Patients in the obese group underwent UKA at a significantly younger mean age (56.5 years (sd 6.4)) than those in the control group (62.4 years (sd 7.8); p < 0.001). There was no significant difference in preoperative functional scores. However, those in the obese group had a significantly lower ROM (116° (sd 15°) vs 123° (sd 17°); p = 0.003). Both groups achieved significant improvement in outcome scores regardless of BMI, ten years postoperatively. All patients achieved the minimal clinically important difference (MCID) for OKS and KSS. Both groups also had high rates of satisfaction (96.3% in the control group and 97.5% in the obese group) and the fulfilment of expectations (94.9% in the control group and 95.0% in the obese group). Multiple linear regression showed a clear association between obesity and a lower OKS two years postoperatively and Knee Society Function Score (KSFS) ten years postoperatively. After applying propensity matching, obese patients had a significantly lower KSFS, OKS, and physical component score (PCS) ten years postoperatively. Seven patients underwent revision to total knee arthroplasty (TKA), two in the control group and five in the obese group, resulting in a mean rate of survival at ten years of 98.6% and 88.1%, respectively (p = 0.012).
Both groups had significant improvements in functional and quality-of-life scores postoperatively. However, obesity was a significant predictor of poorer improvement in clinical outcome and an increased rate of revision ten years postoperatively.
本研究旨在评估肥胖对接受固定衬垫单髁膝关节置换术(UKA)后十年临床结果和存活率的影响。
我们前瞻性随访了 2003 年至 2007 年间接受 UKA 的 184 例患者,随访时间至少 10 年。共有 142 例术前体重指数(BMI)<30kg/m 的患者纳入对照组(32 名男性,110 名女性),42 例 BMI≥30kg/m 的患者纳入肥胖组(5 名男性,37 名女性)。分析术前和术后的活动范围(ROM)、膝关节学会评分(KSS)、牛津膝关节评分(OKS)、36 项简明健康调查(SF-36)和存活率。
肥胖组患者的 UKA 手术平均年龄明显低于对照组(56.5 岁(sd 6.4)比 62.4 岁(sd 7.8);p<0.001)。术前功能评分无显著差异。然而,肥胖组的 ROM 显著较低(116°(sd 15°)比 123°(sd 17°);p=0.003)。两组患者无论 BMI 如何,术后 10 年均取得了显著的疗效改善。所有患者均达到了 OKS 和 KSS 的最小临床重要差异(MCID)。两组患者的满意度均很高(对照组为 96.3%,肥胖组为 97.5%),对治疗的期望均得到了满足(对照组为 94.9%,肥胖组为 95.0%)。多元线性回归显示,肥胖与术后两年的 OKS 评分和膝关节学会功能评分(KSFS)较低有明显关联。应用倾向评分匹配后,肥胖患者术后 10 年的 KSFS、OKS 和生理成分评分(PCS)明显较低。7 例患者行翻修全膝关节置换术(TKA),对照组 2 例,肥胖组 5 例,术后 10 年的平均生存率分别为 98.6%和 88.1%(p=0.012)。
两组患者术后在功能和生活质量评分方面均有显著改善。然而,肥胖是术后临床疗效改善较差和翻修率增加的一个显著预测因素。