Bielen E, Fagard R, Lijnen P, Amery A
Department of Pathophysiology, University of Leuven, Belgium.
J Hum Hypertens. 1988 Oct;2(3):167-70.
Plasma renin activity, renin concentration and aldosterone concentration were measured in 78 untreated hypertensive patients aged 60-83 years. In a cross-sectional analysis, plasma renin activity, renin concentration and aldosterone concentration showed no relationship with age. Half of these patients were subsequently followed on placebo over a 3-year period during which the plasma constituents of the renin-angiotensin-aldosterone system remained stable. From these cross-sectional and longitudinal observations we conclude that beyond the age of 60 ageing has no detectable effect on plasma renin and aldosterone levels in these elderly hypertensive patients.
对78名年龄在60 - 83岁之间未经治疗的高血压患者测量了血浆肾素活性、肾素浓度和醛固酮浓度。在横断面分析中，血浆肾素活性、肾素浓度和醛固酮浓度与年龄无关。随后，其中一半患者接受了为期3年的安慰剂随访，在此期间肾素 - 血管紧张素 - 醛固酮系统的血浆成分保持稳定。从这些横断面和纵向观察中我们得出结论，在60岁以上，衰老对这些老年高血压患者的血浆肾素和醛固酮水平没有可检测到的影响。
