Mazurek W, Negrusz-Kawecka M
Katedry i Kliniki Kardiologii, Akademii Medycznej we Wrocławiu.
Pol Merkur Lekarski. 1999 Oct;7(40):159-63.
The purpose of this study was to investigate whether the renin-angiotensin-aldosterone system activity RAAA or plasma catecholamines concentrations and blood pressure are related to distinct patterns of drinking one cup of coffee in hypertensive patients with low or normal plasma renin activity. Plasma renin activity and enzyme converting angiotensin I to angiotensin II activity and serum concentration of aldosterone and catecholamines were measured by radioimmunoassay. Blood pressure was measured by ambulatory monitoring. Our data suggest that drinking one cup of coffee caused after 60 min, to 2 hours elevated systolic and after 60 min diastolic pressure, only in hypertensive patients, with low RAAA habitually drinking coffee. Hypertensive patients with normal RAAA, habitually drinking coffee, after drinking one cup of coffee had elevation only of diastolic blood pressure from 60 min to 120 min after drinking, but systolic blood pressure did not elevate. Plasma catecholamines and aldosterone concentrations, blood renin activity and enzyme converting angiotensin I to angiotensin II activity were not elevated in hypertensive patients with low or normal RAAA after drinking one cup of coffee.
本研究的目的是调查在血浆肾素活性低或正常的高血压患者中，肾素-血管紧张素-醛固酮系统活性（RAAA）或血浆儿茶酚胺浓度与血压是否与饮用一杯咖啡的不同模式有关。采用放射免疫分析法测定血浆肾素活性、将血管紧张素I转化为血管紧张素II的酶活性、醛固酮和儿茶酚胺的血清浓度。通过动态监测测量血压。我们的数据表明，仅在习惯性喝咖啡且RAAA较低的高血压患者中，饮用一杯咖啡后60分钟至2小时收缩压升高，60分钟后舒张压升高。习惯性喝咖啡且RAAA正常的高血压患者，饮用一杯咖啡后，仅在饮用后60分钟至120分钟舒张压升高，但收缩压未升高。饮用一杯咖啡后，RAAA低或正常的高血压患者血浆儿茶酚胺和醛固酮浓度、血液肾素活性以及将血管紧张素I转化为血管紧张素II的酶活性均未升高。
