France C, Ditto B
Department of Psychology, McGill University, Montreal, Quebec, Canada.
J Behav Med. 1988 Oct;11(5):473-82. doi: 10.1007/BF00844840.
The effects of caffeine on cardiovascular responses to a mental arithmetic task were assessed using a between-subjects, double-blind design. Thirty-six male undergraduates were randomly assigned to either a placebo group or a group which received 250mg of caffeine. Repeated measurements of systolic and diastolic blood pressure (SBP, DBP), heart rate (HR), digital blood volume pulse (DBVP), and finger pulse transit time (FPTT) were obtained during a predrug baseline, a postdrug resting period, and a mental arithmetic task. Significant Period (i.e., stress) effects were observed on all measures, except DBVP which revealed a marginally significant Period effect. Significant main effects of Drug were observed on DBP and DBVP. There were no significant Drug x Period interactions. These results indicate that the increases in DBP and the decreases in DBVP produced by caffeine were additive with effects produced by stress.
采用组间双盲设计评估咖啡因对心算任务心血管反应的影响。36名男性本科生被随机分为安慰剂组或接受250毫克咖啡因的组。在用药前基线、用药后静息期和心算任务期间，重复测量收缩压和舒张压（SBP、DBP）、心率（HR）、数字血容量脉搏（DBVP）和手指脉搏传输时间（FPTT）。除DBVP显示出边缘显著的时期效应外，在所有测量指标上均观察到显著的时期（即应激）效应。在DBP和DBVP上观察到药物的显著主效应。没有显著的药物×时期交互作用。这些结果表明，咖啡因引起的DBP升高和DBVP降低与应激产生的效应具有叠加性。
