Division of Reproductive Endocrinology and Infertility, Department of Obstetrics and Gynecology, McGill University, Montreal, Canada.
Division of Cardiovascular Medicine, Department of Internal Medicine, Stanford University, Stanford, USA.
J Endocrinol Invest. 2019 Aug;42(8):987-993. doi: 10.1007/s40618-019-01014-9. Epub 2019 Jan 30.
To evaluate the relationship between surrogate estimates of insulin resistance and a direct measurement of insulin-mediated glucose uptake women with and without PCOS.
Retrospective cohort study of 75 PCOS and 118 controls. Fasting plasma glucose and insulin concentrations, insulin resistance as determined by the insulin suppression test, calculation of multiple surrogate estimates of insulin resistance, total and free testosterone concentrations, and correlations between the direct measure and surrogate estimates of insulin resistance were evaluated.
RESULT(S): Surrogate markers of insulin resistance were correlated to a variable, but statistically significant degree with the direct measure of insulin resistance in control population and the women with PCOS. There was no correlation between the surrogate estimates of insulin resistance and total or free plasma testosterone concentrations.
CONCLUSION(S): The surrogate estimates of insulin resistance evaluated were significantly related to a direct measure of insulin resistance, and this was true of both the control population and women with PCOS. The magnitude of the relationship between the surrogate estimates and the direct measurement was comparable and not significantly altered by androgen levels. Fasting plasma insulin concentration seems to be at least as accurate as any other surrogate estimate, and is by far the simplest.
评估胰岛素抵抗的替代指标与直接测量多囊卵巢综合征（PCOS）和非 PCOS 妇女胰岛素介导的葡萄糖摄取之间的关系。
对 75 例 PCOS 和 118 例对照进行回顾性队列研究。评估空腹血糖和胰岛素浓度、胰岛素抑制试验确定的胰岛素抵抗、多种胰岛素抵抗替代指标的计算、总睾酮和游离睾酮浓度，以及直接测量和胰岛素抵抗替代指标之间的相关性。
在对照组和 PCOS 妇女中，胰岛素抵抗的替代指标与直接测量的胰岛素抵抗呈显著相关，但相关性存在一定差异。胰岛素抵抗替代指标与总或游离血浆睾酮浓度之间无相关性。
评估的胰岛素抵抗替代指标与直接测量的胰岛素抵抗显著相关，这在对照组和 PCOS 妇女中都是如此。替代指标与直接测量之间的关系程度相当，雄激素水平对其没有显著影响。空腹胰岛素浓度似乎与任何其他替代指标一样准确，而且简单得多。
