Zhao Hang, Tang Yong, Zheng Chong, Ren Luping, Song Guangyao
Endocrinology Department, Hebei General Hospital, Shijiazhuang, Hebei, 050051, People's Republic of China.
Pediatric Orthopaedics, Shijiazhuang the Third Hospital, Shijiazhuang, Hebei, 050011, People's Republic of China.
Risk Manag Healthc Policy. 2021 Apr 7;14:1393-1399. doi: 10.2147/RMHP.S299963. eCollection 2021.
This study aimed to examine whether 25-hydroxyvitamin D (25OHD) levels (an indicator of vitamin D status) are independently associated with insulin resistance (IR) in patients with type 2 diabetes mellitus (T2DM).
This was a cross-sectional study. Participants with T2DM were recruited from the Department of Endocrinology in Hebei General Hospital according to inclusion and exclusion criteria. Data on basic characteristics and blood parameters were collected. We used the IR index (20/[fasting C-peptide × fasting plasma glucose]) to evaluate IR. Potential confounding factors were selected from comparisons among different IR index groups of quartiles and were adjusted in different models.
We included 172 subjects (121 men and 51 women) whose mean age was 53.2±10.6 years. Body mass index (BMI), DM course, insulin use, glycated hemoglobin (HbA1c), fasting blood glucose, fasting C-peptide, triglycerides (TG), high-density lipoprotein cholesterol (HDL-C), apolipoprotein A1 (ApoA1), and albumin were differed among different IR-index groups (all P value <0.05). In models 1 and 2, no or some confounding factors were adjusted for, and we found that there was no relationship between 25OHD and the IR index. In model 3, when all confounding factors (DM course, insulin use, BMI, HbA1c, TG, HDL-C, ApoA1, albumin and other bone turnover markers) were adjusted for, the IR index was increased by 5.6% when 25OHD levels increased by 1 ng/mL (odds ratio: 1.056; 95% confidence interval: 1.009, 1.105).
Vitamin D is independently associated with IR in patients with T2DM.
本研究旨在探讨25-羟维生素D（25OHD）水平（维生素D状态指标）是否与2型糖尿病（T2DM）患者的胰岛素抵抗（IR）独立相关。
这是一项横断面研究。根据纳入和排除标准，从河北医科大学第一医院内分泌科招募T2DM患者。收集基本特征和血液参数数据。我们使用IR指数（20/[空腹C肽×空腹血糖]）评估IR。从四分位数的不同IR指数组间比较中选择潜在混杂因素，并在不同模型中进行调整。
我们纳入了172名受试者（121名男性和51名女性），平均年龄为53.2±10.6岁。不同IR指数组间的体重指数（BMI）、糖尿病病程、胰岛素使用情况、糖化血红蛋白（HbA1c）、空腹血糖、空腹C肽、甘油三酯（TG）、高密度脂蛋白胆固醇（HDL-C）、载脂蛋白A1（ApoA1）和白蛋白存在差异（所有P值<0.05）。在模型1和模型2中，未调整或调整了一些混杂因素，我们发现25OHD与IR指数之间无关联。在模型3中，当调整所有混杂因素（糖尿病病程、胰岛素使用情况、BMI、HbA1c、TG、HDL-C、ApoA1、白蛋白和其他骨转换标志物）后，25OHD水平每升高1 ng/mL，IR指数增加5.6%（优势比：1.056；95%置信区间：1.009，1.105）。
维生素D与T2DM患者的IR独立相关。
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