Pasternack G R, Johnson R J, Shin H S
J Immunol. 1978 May;120(5):1560-6.
In a murine system, macrophages, in concert with antibody, were shown to suppress iododeoxyuridine incorporation by tumor cells. The mechanism of suppression did not involve phagocytosis or lysis. The generation of suppressed tumor cells was resolved into a contact-dependent step and a contact-independent step. The first step was one-hit with respect to macrophages and multi-hit with respect to antibody.
在小鼠系统中，巨噬细胞与抗体协同作用，可抑制肿瘤细胞摄取碘脱氧尿苷。抑制机制不涉及吞噬作用或细胞裂解。被抑制的肿瘤细胞的产生可分为接触依赖性步骤和接触非依赖性步骤。第一步对巨噬细胞而言是单次打击，对抗体而言是多次打击。
