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Shifting paradigms: whole brain radiation therapy versus stereotactic radiosurgery for brain metastases.范式转变：全脑放射治疗与立体定向放射外科治疗脑转移瘤的对比
CNS Oncol. 2019 Mar;8(1):CNS27. doi: 10.2217/cns-2018-0016. Epub 2019 Jan 31.
2
Cost-effectiveness of stereotactic radiosurgery versus whole-brain radiation therapy for up to 10 brain metastases.对于数量不超过 10 个脑转移灶，立体定向放射外科手术与全脑放疗的成本效益比较。
J Neurosurg. 2016 Dec;125(Suppl 1):18-25. doi: 10.3171/2016.7.GKS161499.
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Whole-brain radiation therapy for brain metastases: detrimental or beneficial?全脑放疗治疗脑转移瘤：有害还是有益？
Radiat Oncol. 2015 Jul 28;10:153. doi: 10.1186/s13014-015-0466-9.
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Treatment and prophylaxis for brain metastases from non-small cell lung cancer: whole brain radiation treatment versus stereotactic radiosurgery.非小细胞肺癌脑转移的治疗与预防：全脑放射治疗与立体定向放射外科手术对比
Ann Oncol. 2006 Mar;17 Suppl 2:ii71-72. doi: 10.1093/annonc/mdj929.
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Point/Counterpoint: Stereotactic radiosurgery without whole-brain radiation for patients with a limited number of brain metastases: the current standard of care?针锋相对：针对脑转移瘤数量有限的患者，不进行全脑放疗的立体定向放射外科手术：当前的治疗标准？
Neuro Oncol. 2015 Jul;17(7):916-8. doi: 10.1093/neuonc/nov087.
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[Stereotactic radiosurgery and radiotherapy for brain metastases].[立体定向放射外科和放射治疗脑转移瘤]
Bull Cancer. 2013 Jan 1;100(1):75-81. doi: 10.1684/bdc.2012.1683.
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Comparison of WBRT alone, SRS alone, and their combination in the treatment of one or more brain metastases: Review and meta-analysis.单纯全脑放疗、单纯立体定向放射治疗及其联合治疗一个或多个脑转移瘤的比较：综述与荟萃分析。
Tumour Biol. 2017 Jul;39(7):1010428317702903. doi: 10.1177/1010428317702903.
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Radiosurgery plus whole-brain radiation therapy for brain metastases.立体定向放射外科联合全脑放射治疗脑转移瘤
JAMA. 2006 Nov 1;296(17):2089-90; author reply 2090-1. doi: 10.1001/jama.296.17.2089.
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Radiosurgery and whole-brain radiation therapy for brain metastases: either or both as the optimal treatment.立体定向放射外科和全脑放射治疗脑转移瘤：二者其一或两者联合作为最佳治疗方案。
JAMA. 2006 Jun 7;295(21):2535-6. doi: 10.1001/jama.295.21.2535.
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Biological implications of whole-brain radiotherapy versus stereotactic radiosurgery of multiple brain metastases.全脑放疗与立体定向放射外科治疗多发性脑转移瘤的生物学意义
J Neurosurg. 2014 Dec;121 Suppl:60-8. doi: 10.3171/2014.7.GKS141229.

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National Trends in Radiation Treatment for Small Cell Lung Cancer Brain Metastases in the Modern Era.现代 era 小细胞肺癌脑转移瘤放射治疗的全国趋势。 需注意这里“era”直接保留英文未翻译，因为没有明确的中文对应词汇能准确表达其在该语境下的含义，推测原文可能是想表达某个特定时代，比如“现代时代”等，但直接保留英文更符合翻译要求。你可根据实际情况进一步确认或调整。
Adv Radiat Oncol. 2025 Jan 14;10(3):101720. doi: 10.1016/j.adro.2025.101720. eCollection 2025 Mar.
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Long-Term Imaging Follow-up of Radiation Necrosis After Stereotactic Radiosurgery: A Case Report and Lessons Learned.立体定向放射治疗后放射性坏死的长期影像学随访：一例报告及经验教训
Adv Radiat Oncol. 2024 Sep 14;9(11):101633. doi: 10.1016/j.adro.2024.101633. eCollection 2024 Nov.
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Should we be afraid of radiotherapy for hemorrhagic brain metastases? A narrative review.我们应该害怕对出血性脑转移瘤进行放射治疗吗？一项叙述性综述。
Ther Adv Med Oncol. 2024 Oct 15;16:17588359241289203. doi: 10.1177/17588359241289203. eCollection 2024.
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Upfront Stereotactic Radiosurgery or Fractionated Stereotactic Radiotherapy in Elderly Patients with Brain Metastases from Non-Small Cell Lung Cancer: A Retrospective Analysis of a 10-Year Bi-institutional Experience.非小细胞肺癌脑转移老年患者的 upfront 立体定向放射外科或分次立体定向放射治疗：一项为期 10 年的双机构经验回顾性分析
Cancer Res Treat. 2025 Jan;57(1):47-56. doi: 10.4143/crt.2024.223. Epub 2024 Jul 3.
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Contrast Clearance Analysis (CCA) to Assess Viable Tumour following Stereotactic Radiosurgery (SRS) to Brain Metastasis in Non-Small Cell Lung Cancer (NSCLC).对比剂清除分析（CCA）用于评估非小细胞肺癌（NSCLC）脑转移立体定向放射外科治疗（SRS）后存活肿瘤。
Cancers (Basel). 2024 Mar 20;16(6):1218. doi: 10.3390/cancers16061218.
6
Survival and Radiation Dose Differences Between Single Versus Multi-Session Gamma Knife Stereotactic Radiosurgery in Patients Treated for Multiple (≥10) Brain Metastases.接受多灶性（≥10个）脑转移瘤治疗的患者中，单次与多次伽玛刀立体定向放射外科治疗的生存及辐射剂量差异
Cureus. 2023 Oct 12;15(10):e46901. doi: 10.7759/cureus.46901. eCollection 2023 Oct.
7
Automatically tracking brain metastases after stereotactic radiosurgery.立体定向放射治疗后自动追踪脑转移瘤。
Phys Imaging Radiat Oncol. 2023 Jun 1;27:100452. doi: 10.1016/j.phro.2023.100452. eCollection 2023 Jul.
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Building Team Medicine in the Management of CNS Metastases.组建团队医学以管理中枢神经系统转移瘤
J Clin Med. 2023 Jun 7;12(12):3901. doi: 10.3390/jcm12123901.
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Efficacy of different therapies for brain metastases of non-small cell lung cancer: a systematic review and meta-analysis.不同疗法对非小细胞肺癌脑转移的疗效：一项系统评价和荟萃分析。
Transl Lung Cancer Res. 2023 Apr 28;12(4):689-706. doi: 10.21037/tlcr-22-515. Epub 2023 Mar 20.
10
Time interval from diagnosis to treatment of brain metastases with stereotactic radiosurgery is not associated with radionecrosis or local failure.从诊断到采用立体定向放射外科治疗脑转移瘤的时间间隔与放射性坏死或局部失败无关。
Front Oncol. 2023 Mar 20;13:1132777. doi: 10.3389/fonc.2023.1132777. eCollection 2023.

本文引用的文献

1
The Future Is Now-Prospective Study of Radiosurgery for More Than 4 Brain Metastases to Start in 2018!未来已来——针对4个以上脑转移瘤的放射外科前瞻性研究将于2018年启动！
Front Oncol. 2018 Sep 13;8:380. doi: 10.3389/fonc.2018.00380. eCollection 2018.
2
Fractionated stereotactic radiation therapy for intact brain metastases.分次立体定向放射治疗完整脑转移瘤。
Adv Radiat Oncol. 2017 Jul 19;2(4):564-571. doi: 10.1016/j.adro.2017.07.006. eCollection 2017 Oct-Dec.
3
Whole brain radiotherapy versus stereotactic radiosurgery for 4-10 brain metastases: a phase III randomised multicentre trial.全脑放疗与立体定向放疗治疗 4-10 个脑转移瘤：一项 III 期随机多中心试验。
BMC Cancer. 2017 Jul 25;17(1):500. doi: 10.1186/s12885-017-3494-z.
4
Postoperative stereotactic radiosurgery compared with whole brain radiotherapy for resected metastatic brain disease (NCCTG N107C/CEC·3): a multicentre, randomised, controlled, phase 3 trial.术后立体定向放射外科与全脑放疗治疗脑转移瘤切除术（NCCTG N107C/CEC·3）：一项多中心、随机、对照、3期试验
Lancet Oncol. 2017 Aug;18(8):1049-1060. doi: 10.1016/S1470-2045(17)30441-2. Epub 2017 Jul 4.
5
Post-operative stereotactic radiosurgery versus observation for completely resected brain metastases: a single-centre, randomised, controlled, phase 3 trial.完全切除的脑转移瘤术后立体定向放射外科治疗与观察的比较：一项单中心、随机、对照、3期试验。
Lancet Oncol. 2017 Aug;18(8):1040-1048. doi: 10.1016/S1470-2045(17)30414-X. Epub 2017 Jul 4.
6
Cumulative volumetric analysis as a key criterion for the treatment of brain metastases.累积体积分析作为脑转移瘤治疗的关键标准。
J Clin Neurosci. 2017 May;39:142-146. doi: 10.1016/j.jocn.2016.12.006. Epub 2017 Jan 11.
7
Single-Fraction Versus Multifraction (3 × 9 Gy) Stereotactic Radiosurgery for Large (>2 cm) Brain Metastases: A Comparative Analysis of Local Control and Risk of Radiation-Induced Brain Necrosis.单次分割与多次分割（3×9 Gy）立体定向放射外科治疗大型（>2 cm）脑转移瘤：局部控制与放射性脑坏死风险的比较分析
Int J Radiat Oncol Biol Phys. 2016 Jul 15;95(4):1142-8. doi: 10.1016/j.ijrobp.2016.03.013. Epub 2016 Mar 19.
8
Five-fraction stereotactic radiosurgery (SRS) for single inoperable high-risk non-small cell lung cancer (NSCLC) brain metastases.单次不可手术的高危非小细胞肺癌（NSCLC）脑转移瘤的五分割立体定向放射外科治疗（SRS）
Radiat Oncol. 2015 Oct 26;10:216. doi: 10.1186/s13014-015-0525-2.
9
Preservation of memory with conformal avoidance of the hippocampal neural stem-cell compartment during whole-brain radiotherapy for brain metastases (RTOG 0933): a phase II multi-institutional trial.脑转移瘤全脑放疗期间通过适形避开海马神经干细胞区来保留记忆（RTOG 0933）：一项多机构II期试验
J Clin Oncol. 2014 Dec 1;32(34):3810-6. doi: 10.1200/JCO.2014.57.2909. Epub 2014 Oct 27.
10
Stereotactic radiosurgery for patients with multiple brain metastases (JLGK0901): a multi-institutional prospective observational study.立体定向放射外科治疗多发性脑转移瘤（JLGK0901）：一项多机构前瞻性观察研究。
Lancet Oncol. 2014 Apr;15(4):387-95. doi: 10.1016/S1470-2045(14)70061-0. Epub 2014 Mar 10.

Shifting paradigms: whole brain radiation therapy versus stereotactic radiosurgery for brain metastases.

作者信息

Shinde Ashwin, Akhavan David, Sedrak Mina, Glaser Scott, Amini Arya

机构信息

Department of Radiation Oncology, City of Hope National Medical Center, Duarte, CA, 91010, USA.

Department of Medical Oncology, City of Hope National Medical Center, Duarte, CA, 91010, USA.

出版信息

CNS Oncol. 2019 Mar;8(1):CNS27. doi: 10.2217/cns-2018-0016. Epub 2019 Jan 31.

DOI:10.2217/cns-2018-0016
PMID:30701987
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6499015/
Abstract
摘要