Department of Psychiatry, Southern Medical University Nanfang Hospital, Guangzhou, Guangdong, China.
Unit of Psychiatry, Faculty of Health Sciences, University of Macau, Macau SAR, China.
Psychooncology. 2019 Apr;28(4):675-686. doi: 10.1002/pon.5013. Epub 2019 Feb 17.
The current systematic review aims to provide an overview of fear of cancer recurrence (FCR) in adolescent and young adult cancer survivors (15-39 years at cancer diagnosis, AYAs).
MEDLINE, PubMed, PsycINFO, and Embase databases were independently searched to identify relevant quantitative articles. PRISMA systematic review procedures were followed with quality assessment.
Seventeen studies were included in the current review. All were quantitative studies that utilized a cross-sectional study design. Seven articles reported results of FCR prevalence, six studied determinants related to FCR, and 11 articles provided information about consequences of FCR. Prevalence of FCR ranged from 31% to 85.2% among AYA survivors. Associations between sociodemographic/clinical variables and FCR were inconsistent. Psychological distress and higher treatment intensity were positively associated with higher FCR levels. Lower scores on levels of physical, psychological functioning, and overall health-related quality of life (QoL) were identified as consequences of increased FCR.
FCR appears to be a prevalent concern among adolescent and young adult cancer populations. Adequate assessment to determine need for support and intervention is still required. Longitudinal studies in AYAs are warranted to understand the development and potential influence of FCR. Age-appropriate and flexible psychological care would be more successful potentially with this crucial background information.
本系统评价旨在概述青少年和年轻成年癌症幸存者（癌症诊断时年龄为 15-39 岁，AYAs）的癌症复发恐惧（FCR）。
我们独立检索了 MEDLINE、PubMed、PsycINFO 和 Embase 数据库，以确定相关的定量文章。遵循 PRISMA 系统评价程序并进行质量评估。
本综述纳入了 17 项研究。所有研究均为采用横断面研究设计的定量研究。7 篇文章报告了 FCR 流行率的结果，6 篇研究了与 FCR 相关的决定因素，11 篇文章提供了 FCR 后果的信息。AYA 幸存者中 FCR 的流行率从 31%到 85.2%不等。社会人口统计学/临床变量与 FCR 之间的关联不一致。心理困扰和更高的治疗强度与更高的 FCR 水平呈正相关。较高的 FCR 水平与身体、心理功能以及整体健康相关生活质量（QoL）评分降低有关。
FCR 似乎是青少年和年轻成年癌症人群中普遍存在的问题。仍需要进行充分的评估，以确定是否需要支持和干预。需要在 AYAs 中进行纵向研究，以了解 FCR 的发展及其潜在影响。具有这一重要背景信息的适合年龄的灵活心理护理可能会更成功。
