Vaisman N, Pencharz P B, Geary D F, Harrison J E
Division of Clinical Nutrition, Hospital for Sick Children, Ont., Canada.
Nephron. 1988;50(4):282-7. doi: 10.1159/000185188.
Rapid weight gain has been observed following kidney transplantation. To determine the accompanying changes in body composition, we studied 8 patients (7 females, 1 male) aged 3-17.5 years who underwent renal transplantation. Body composition measurements included weight, height, triceps skinfold thickness, total body potassium, total body water, and extracellular water. Excessive weight gain was observed in most of the patients. Weight as a percentage of ideal weight for height increased from 96.0 +/- 13.8 to 116.3 +/- 13.0% (p less than 0.01). This was accompanied by a gain in fat mass in the first 3 months and a subsequent increase in lean body mass in the next 3 months. Extracellular water was increased before transplantation (32.9 +/- 6.5% of body weight) and returned to normal (27.3 +/- 8.6%) 3 months after transplantation (p less than 0.01). The weight gain following kidney transplantation in children resulted mainly from increases in adipose tissue and lean body mass, and was not related to water retention.
肾移植后观察到体重迅速增加。为了确定身体成分的相应变化，我们研究了8例年龄在3至17.5岁之间接受肾移植的患者（7名女性，1名男性）。身体成分测量包括体重、身高、肱三头肌皮褶厚度、总体钾、总体水和细胞外液。大多数患者出现体重过度增加。身高的理想体重百分比从96.0±13.8增加到116.3±13.0%（p<0.01）。这伴随着前3个月脂肪量的增加以及随后3个月瘦体重的增加。移植前细胞外液增加（占体重的32.9±6.5%），移植后3个月恢复正常（27.3±8.6%）（p<0.01）。儿童肾移植后的体重增加主要源于脂肪组织和瘦体重的增加，与水潴留无关。
