[Plasma, renal and tumor determination of total platinum during predictive tests of chemosensitivity of human tumor implants in the renal capsule in syngeneic mice].

During the study of chemotherapy responsiveness of twenty nine human tumors by 6 day subrenal capsule assay (SRCA), we measured, after cisplatinum regimen, the total platinum in human tumor implants and in mice plasma and renal tissue. The plasmatic (m = 0.36 +/- 0.13 microgram/ml) and renal (m = 16.1 +/- 6.4 ng/ml) total platinum concentrations are correlated. In human tumor implants the total platinum is measurable in only ten cases (above the minimum value of 7 ng/mg). There are no correlation between the tumor total platinum concentrations and the tumor cisplatinum chemosensitivity. The study is an example of anti-cancer drugs dosage in SRCA.