Horvath E
St. Michael's Hospital, Department of Pathology University of Toronto, Ontario, Canada.
Pathol Res Pract. 1988 Sep;183(5):631-3. doi: 10.1016/S0344-0338(88)80028-1.
The ultrastructural features and immunohistochemical characteristics of nontumorous adenohypophysial cells in the human pituitary are briefly reviewed and the usefulness of electron microscopy and immunoelectron microscopy is stressed in cell identification. Recent immunoelectron microscopic studies demonstrate the presence of plurihormonal cells containing more than one hormone, not only in pituitary adenomas but also in nontumorous adenohypophyses. These results lead to the conclusion that the one cell- one hormone theory, which dominated pituitary cytophysiology and cytopathology for several decades, is untenable.
简要回顾了人类垂体中非肿瘤性腺垂体细胞的超微结构特征和免疫组化特性，并强调了电子显微镜和免疫电子显微镜在细胞鉴定中的作用。最近的免疫电子显微镜研究表明，不仅在垂体腺瘤中，而且在非肿瘤性腺垂体中都存在含有不止一种激素的多激素细胞。这些结果得出这样的结论：几十年来主导垂体细胞生理学和细胞病理学的“一个细胞一种激素”理论是站不住脚的。
