Quantum reference beacon-guided superresolution optical focusing in complex media.

Optical scattering is generally considered to be a nuisance of microscopy that limits imaging depth and spatial resolution. Wavefront shaping techniques enable optical imaging at unprecedented depth, but attaining superresolution within complex media remains a challenge. We used a quantum reference beacon (QRB), consisting of solid-state quantum emitters with spin-dependent fluorescence, to provide subwavelength guidestar feedback for wavefront shaping to achieve a superresolution optical focus. We implemented the QRB-guided imaging with nitrogen-vacancy centers in diamond nanocrystals, which enable optical focusing with a subdiffraction resolution below 186 nanometers (less than half the wavelength). QRB-assisted wavefront-shaping should find use in a range of applications, including deep-tissue quantum enhanced sensing and individual optical excitation of magnetically coupled spin ensembles for applications in quantum information processing.