Kingston University London, Cancer theme, School of Life Science, Pharmacy and Chemistry, SEC Faculty, Kingston upon Thames, KT1 2EE, London, UK.
Kingston University London, School of Life Science, Pharmacy and Chemistry, SEC Faculty, Kingston upon Thames, KT1 2EE, London, UK.
Sci Rep. 2019 Jan 31;9(1):1013. doi: 10.1038/s41598-018-37665-6.
Infection caused by high-risk human papillomaviruses (HPVs) are implicated in the aetiology of cervical cancer. Although current methods of treatment for cervical cancer can ablate lesions, preventing metastatic disseminations and excessive tissue injuries still remains a major concern. Hence, development of a safer and more efficient treatment modality is of vital importance. Natural products from plants are one of the principal sources of precursors to lead compounds with direct pharmaceutical application across all disease classes. One of these plants is Ficus carica, whose fruit latex, when applied on HPV-induced skin warts, has shown potential as a possible cure for this virus related lesions. This study explores the in vitro biological activities of fig latex and elucidates its possible mechanisms of action on cervical cancer cell lines CaSki and HeLa positive for HPV type 16 and 18, respectively. Our data shows that fig latex inhibits properties that are associated with HPV-positive cervical cancer transformed cells such as rapid growth and invasion and substantially downregulated the expression of p16 and HPV onco-proteins E6, E7. These findings suggest Ficus carica latex has the potential to be used in the development of therapeutic modalities for the possible treatment, cure and prevention of HPV related cervical cancer.
高危型人乳头瘤病毒（HPV）感染与宫颈癌的病因有关。尽管目前治疗宫颈癌的方法可以消除病变，但预防转移扩散和过度组织损伤仍然是一个主要关注点。因此，开发更安全、更有效的治疗方法至关重要。植物来源的天然产物是先导化合物的主要来源之一，这些先导化合物具有直接的药物应用潜力，涵盖了所有疾病类别。其中一种植物是无花果，其果实乳胶在治疗 HPV 引起的皮肤疣时显示出作为治疗这种病毒相关病变的潜在可能。本研究探讨了无花果乳胶的体外生物学活性，并阐明了其对 HPV 16 和 18 型阳性的宫颈癌细胞系 CaSki 和 HeLa 的可能作用机制。我们的数据表明，无花果乳胶抑制了与 HPV 阳性宫颈癌转化细胞相关的特性，如快速生长和侵袭，并显著下调了 p16 和 HPV 致癌蛋白 E6、E7 的表达。这些发现表明，无花果乳胶有可能用于开发治疗方法，以治疗、治愈和预防 HPV 相关的宫颈癌。
