Jilin Medical University, 132013, PR China.
Beihua University, 132013, PR China.
J Pharmacol Sci. 2019 Jul;140(3):211-217. doi: 10.1016/j.jphs.2019.06.013. Epub 2019 Aug 10.
Human papillomaviruses (HPVs), for instance, HPV 16 and HPV 18, are concerned associated with cervical cancer. Thus, it is essential to suppress HPVs-in HPV-positive cervical cancer for treating cervical cancer. The purpose of this study was to explore the proposed molecular mechanisms, which that underlies the antintumor potential of juglone to treat of HPV-positive on cervical cancer cells. The results showed that juglone suppressed HPV-positive cell growth in a dose- and time-dependent way. In addition, cell invasion and metastasis were also inhibited by juglone. Nevertheless, when pin 1 was knocked down in HPV-positive cells, cell proliferation, invasion and metastasis were reduced. This study was designed to acquire an understanding of the mechanism of invasion and metastasis in HPV-positive cells suppressed by juglone. It provides evidence of the advantageous use of juglone in the future.
人乳头瘤病毒（HPV），例如 HPV16 和 HPV18，与宫颈癌有关。因此，抑制 HPV 阳性宫颈癌中的 HPV 对于治疗宫颈癌至关重要。本研究旨在探讨胡桃醌抑制 HPV 阳性宫颈癌的抗肿瘤潜力的潜在分子机制。结果表明，胡桃醌以剂量和时间依赖的方式抑制 HPV 阳性细胞的生长。此外，胡桃醌还抑制细胞侵袭和转移。然而，当在 HPV 阳性细胞中敲低 pin1 时，细胞增殖、侵袭和转移减少。本研究旨在了解胡桃醌抑制 HPV 阳性细胞侵袭和转移的机制。它为未来胡桃醌的有利应用提供了证据。
