Belovalova I M, Kniazeva A P, Starosel'tseva L K, Perelygina A A
Probl Endokrinol (Mosk). 1988 Nov-Dec;34(6):3-6.
The level of pancreatic hormones was studied in 10 healthy persons and in 40 patients with diabetes mellitus detected for the first time by GTT, their body mass being normal. For assessment of immunoreactive insulin (IRI), the level of proinsulin and biological activity of serum insulin were determined, and these indices were compared with glucose and C-peptide levels. The examinees' inhomogeneity was shown; on the basis of the findings obtained 2 groups were identified. A decrease in the levels of IRI, C-peptide and biological activity of serum insulin in the 1st group indicated a possibility of type I diabetes mellitus in such patients. Hyperinsulinemia, not correlating with glucose and C-peptide, a high percentage of proinsulin and low biological activity of serum insulin were noted in the 2nd group. The study permitted a differentiated approach to assessment of patients and a choice of therapeutic tactics.
对10名健康人和40名首次通过葡萄糖耐量试验（GTT）检测出患有糖尿病且体重正常的患者的胰腺激素水平进行了研究。为评估免疫反应性胰岛素（IRI），测定了胰岛素原水平和血清胰岛素的生物活性，并将这些指标与血糖和C肽水平进行了比较。结果显示受检者存在异质性；根据所得结果确定了2组。第一组中IRI、C肽和血清胰岛素生物活性水平降低表明此类患者可能患有1型糖尿病。第二组中观察到高胰岛素血症，其与血糖和C肽不相关，胰岛素原比例高且血清胰岛素生物活性低。该研究允许采用差异化方法评估患者并选择治疗策略。
