Starosel'tseva L K, Kniazeva A P, Belovalova I M, Abduraimova G R
Probl Endokrinol (Mosk). 1988 Jul-Aug;34(4):20-5.
The paper is concerned with the results of investigation of 26 donors and 85 patients with diabetes mellitus, type II, with normal body mass and obesity during GTT and a test breakfast to reveal correlation of IRI and IRG levels with the level of gastrin. Comparative analysis of indices during OGTT and food intake has shown that an increase in the levels of gastrin in patients with diabetes mellitus, type II, does not correlate with body mass and the total level of insulin, but it may correlate with a metabolically active form of insulin. During food intake the levels of gastrin rise and do not change during GTT. A rise of the level of gastrin in patients with diabetes mellitus, type II, during a test breakfast is accompanied by change in the level of insulin, its peak being lower than that during GTT. Attention was focused on a group of patients with a history of obesity in whom by the time of investigation body mass returned to normal and the level of glucose was decreased. However, gastrin and insulin levels were still high, and metabolic regulation was disturbed. Therefore, body mass normalization did not eliminate causative and pathogenetic factors of diabetes mellitus.
本文关注对26名捐赠者以及85名II型糖尿病患者（包括体重正常和肥胖者）在葡萄糖耐量试验（GTT）和试餐期间进行调查的结果，以揭示胰岛素释放指数（IRI）和胰岛素抵抗指数（IRG）水平与胃泌素水平之间的相关性。对口服葡萄糖耐量试验期间和进食期间各项指标的比较分析表明，II型糖尿病患者胃泌素水平的升高与体重和胰岛素总水平无关，但可能与胰岛素的代谢活性形式相关。进食期间胃泌素水平升高，而在葡萄糖耐量试验期间不变。II型糖尿病患者在试餐期间胃泌素水平升高的同时，胰岛素水平也发生变化，其峰值低于葡萄糖耐量试验期间。研究重点关注了一组有肥胖病史的患者，在调查时他们的体重已恢复正常且血糖水平降低。然而，胃泌素和胰岛素水平仍然很高，代谢调节受到干扰。因此，体重正常化并未消除糖尿病的病因和发病机制因素。
