子痫前期中的肾素-血管紧张素系统：旧事重演。
Renin-angiotensin system in pre-eclampsia: everything old is new again.
作者信息
J Spaan Julia, A Brown Mark
机构信息
Departments of Medicine and Renal Medicine, St George Hospital, University of NSW, Kogarah, NSW, Australia.
出版信息
Obstet Med. 2012 Dec;5(4):147-153. doi: 10.1258/om.2012.120007. Epub 2012 Dec 6.
Abstract
This review presents an update of the role of the renin-angiotensin system in normal pregnancy and pre-eclampsia. We have known for years that the circulatory renin-angiotensin system in pre-eclampsia is suppressed. We now know that the circulating renin-angiotensin system does not only have a vasoconstrictor arm, but also a vasodilator arm, which is upregulated in normal pregnancy; this balance is probably disturbed in pre-eclampsia. Recent studies show the importance of the local renin-angiotensin system in the uteroplacental unit for early placentation and regulation of placental blood flow. We discuss the possible role of autoantibodies against the AT1-receptor in pre-eclampsia and the suggestion that activation of the AT1-receptor in the placenta may lead to placental dysfunction and the clinical syndrome of pre-eclampsia.
摘要
本综述介绍了肾素-血管紧张素系统在正常妊娠和子痫前期中的作用的最新情况。多年来我们已经知道子痫前期的循环肾素-血管紧张素系统受到抑制。现在我们知道循环肾素-血管紧张素系统不仅有血管收缩分支，还有血管舒张分支，后者在正常妊娠中上调；这种平衡在子痫前期可能受到干扰。最近的研究表明局部肾素-血管紧张素系统在子宫胎盘单位对早期胎盘形成和胎盘血流调节的重要性。我们讨论了抗AT1受体自身抗体在子痫前期中的可能作用，以及胎盘AT1受体激活可能导致胎盘功能障碍和子痫前期临床综合征的观点。
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本文引用的文献
1
Markers of cardiovascular disease risk after hypertension in pregnancy.妊娠高血压后心血管疾病风险的标志物。
J Hypertens. 2012 Feb;30(2):351-8. doi: 10.1097/HJH.0b013e32834e5ac7.
2
Detrimental effects of dual ACEI-ARB therapy: is the (pro)renin receptor the culprit?双重 ACEI-ARB 治疗的有害效应：（前）肾素受体是罪魁祸首吗？
Kidney Int. 2011 Nov;80(9):911-914. doi: 10.1038/ki.2011.264.
3
Angiotensin II type 1 receptor antibodies and increased angiotensin II sensitivity in pregnant rats.血管紧张素 II 型 1 型受体抗体和怀孕大鼠血管紧张素 II 敏感性增加。
Hypertension. 2011 Jul;58(1):77-84. doi: 10.1161/HYPERTENSIONAHA.111.171348. Epub 2011 May 16.
4
Maternal/newborn genotype contribution of the renin-angiotensin system (Met235Thr, Thr174Met, I/D-ACE, A2350G-ACE, A1166C-AT2R1, C3123A- AT2R2, 83A/G-REN) to the risk of pre-eclampsia: a Romanian study.母体/新生儿肾素-血管紧张素系统（Met235Thr、Thr174Met、I/D-ACE、A2350G-ACE、A1166C-AT2R1、C3123A-AT2R2、83A/G-REN）基因型对先兆子痫风险的影响：罗马尼亚研究。
J Renin Angiotensin Aldosterone Syst. 2011 Dec;12(4):539-48. doi: 10.1177/1470320311399603. Epub 2011 Mar 24.
5
Regulation of placental growth by aldosterone and cortisol.醛固酮和皮质醇对胎盘生长的调节。
Endocrinology. 2011 Jan;152(1):263-71. doi: 10.1210/en.2010-0525. Epub 2010 Nov 10.
6
Angiotensin II and angiotensin-(1-7) decrease sFlt1 release in normal but not preeclamptic chorionic villi: an in vitro study.血管紧张素 II 和血管紧张素-(1-7)可减少正常但不增加子痫前期绒毛膜绒毛中 sFlt1 的释放：一项体外研究。
Reprod Biol Endocrinol. 2010 Nov 4;8:135. doi: 10.1186/1477-7827-8-135.
7
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J Renin Angiotensin Aldosterone Syst. 2011 Sep;12(3):304-10. doi: 10.1177/1470320310376554. Epub 2010 Aug 11.
8
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Am J Physiol Regul Integr Comp Physiol. 2010 Nov;299(5):R1326-32. doi: 10.1152/ajpregu.00082.2010. Epub 2010 Aug 4.
9
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Hypertens Pregnancy. 2010;29(3):253-61. doi: 10.3109/10641950802001842.
10
Maternal protein restriction reduces angiotensin II AT(1) and AT(2) receptor expression in the fetal rat kidney.母体蛋白限制可降低胎鼠肾脏中血管紧张素 II AT(1)和 AT(2)受体的表达。
Kidney Blood Press Res. 2010;33(4):251-9. doi: 10.1159/000317739. Epub 2010 Jul 2.
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