Tsuchimochi Makoto, Kurabayashi Tohru
The Nippon Dental University (Emeritus Professor), Formerly, Oral and Maxillofacial Radiology, The Nippon Dental University School of Life Dentistry at Niigata, 1-8 Hamaura-cho, Chuo-ku, Niigata 951-8580, Japan.
Department of Oral and Maxillofacial Radiology, Graduate School of Medical and Dental Sciences, Tokyo Medical and Dental University, 1-5-45 Yushima, Bunkyo-ku, Tokyo 113-8549, Japan.
Jpn Dent Sci Rev. 2019 Nov;55(1):1-4. doi: 10.1016/j.jdsr.2018.11.004. Epub 2019 Jan 17.
MRONJ/ARONJ is a serious adverse effect of medication, although the incidence of the disease is rare, and there are still controversial issues regarding the pathogenesis of MRONJ/ARONJ. Medications that can lead to MRONJ/ARONJ are commonly used to treat osteoporosis and to prevent bone fractures caused by bone metastasis of malignancies. The long-standing disease state of ONJ deteriorates the quality of life of affected patients. Early detection and prevention of the disease are key to alleviating pain and discomfort. To date, several imaging modalities have been introduced to depict the lesions. Imaging modalities, radiography, CT, MRI and nuclear medicine provide important information for managing this challenging disease.
下颌骨坏死/非典型性下颌骨坏死是药物治疗的一种严重不良反应，尽管该疾病的发病率很低，并且关于下颌骨坏死/非典型性下颌骨坏死的发病机制仍存在争议。可导致下颌骨坏死/非典型性下颌骨坏死的药物通常用于治疗骨质疏松症以及预防恶性肿瘤骨转移引起的骨折。ONJ的长期疾病状态会降低受影响患者的生活质量。早期检测和预防该疾病是减轻疼痛和不适的关键。迄今为止，已经引入了几种成像方式来描绘病变。成像方式，包括X线摄影、CT、MRI和核医学，为管理这种具有挑战性的疾病提供了重要信息。
