Cudia Diana, Ames James B
Department of Chemistry, University of California, Davis, CA, 95616, USA.
Biomol NMR Assign. 2019 Apr;13(1):201-205. doi: 10.1007/s12104-019-09877-y. Epub 2019 Jan 31.
Retinal membrane guanylyl cyclase (RetGC) in photoreceptor rod and cone cells is regulated by a family of guanylyl cyclase activating proteins (GCAP1-7). GCAP5 is expressed in zebrafish photoreceptors and promotes Ca-dependent regulation of RetGC enzymatic activity that regulates visual phototransduction. We report NMR chemical shift assignments of the Ca-free activator form of GCAP5 (BMRB No. 27705).
视网膜膜鸟苷酸环化酶（RetGC）存在于光感受器视杆细胞和视锥细胞中，受鸟苷酸环化酶激活蛋白家族（GCAP1 - 7）调控。GCAP5在斑马鱼光感受器中表达，并促进RetGC酶活性的钙依赖性调节，而RetGC酶活性调节视觉光转导。我们报道了GCAP5无钙激活剂形式的核磁共振化学位移归属（生物磁共振数据库编号27705）。
