Bhankhur D, Singla N, Aggarwal D, Chander J
Department of Microbiology, Government Medical College and Hospital, Chandigarh, India.
Department of Pulmonary Medicine, Government Medical College and Hospital, Chandigarh, India.
Indian J Pathol Microbiol. 2019 Jan-Mar;62(1):111-113. doi: 10.4103/IJPM.IJPM_205_18.
The link between fungi and asthma has been known for centuries. About one-third to one-half of severe asthmatics has history of atopic sensitization to filamentous fungi, most predominantly to Aspergillus fumigatus. Allergic bronchopulmonary aspergillosis (ABPA) is the one of the most documented fungal presentations among patients with asthma. This study was done on 50 patients with severe asthma who were consecutively enrolled from January 2016 to June 2017 to look for prevalence of ABPA.
Blood samples were collected from 50 patients with severe asthma, and serum was separated to test for absolute eosinophil count, total IgE, and Aspergillus fumigates-specific IgE.
The prevalence of ABPA was found to be 70% (35/50). Of these, ABPA-B (ABPA with bronchiectasis) was less 31.4% (11/35) when compared with 68.5% (24/35) of patients with serological ABPA. Out of these 35 patients, there were 18 females and 17 were males. The mean age of the patients was 41.3 years.
ABPA prevalence is high in patients with severe asthma, and there is a need to look for and evaluate this association further.
真菌与哮喘之间的联系已为人所知达数百年之久。约三分之一至二分之一的重度哮喘患者有对丝状真菌的特应性致敏史，其中最主要的是烟曲霉。变应性支气管肺曲霉菌病（ABPA）是哮喘患者中记录最多的真菌表现之一。本研究对2016年1月至2017年6月连续纳入的50例重度哮喘患者进行，以寻找ABPA的患病率。
采集50例重度哮喘患者的血样，分离血清以检测绝对嗜酸性粒细胞计数、总IgE和烟曲霉特异性IgE。
发现ABPA的患病率为70%（35/50）。其中，与血清学ABPA患者的68.5%（24/35）相比，ABPA-B（伴有支气管扩张的ABPA）较少，为31.4%（11/35）。在这35例患者中，有18名女性和17名男性。患者的平均年龄为41.3岁。
重度哮喘患者中ABPA的患病率较高，需要进一步寻找和评估这种关联。
