Appasani Sreelekha, Ramadas Preethi Thattaruparambil, Gangadharan Jayapriya, Mathews Anitha
Department of Pathology, Regional Cancer Centre, Thiruvananthapuram, Kerala, India.
Indian J Pathol Microbiol. 2019 Jan-Mar;62(1):136-138. doi: 10.4103/IJPM.IJPM_518_17.
Sclerosing polycystic adenosis (SPA) is primarily a disease of major salivary glands. It was recognized as a distinct morphologic entity by Smith et al. in 1996. To best of our knowledge, 67 cases of SPA are reported in English literature. Here, we describe a case of SPA showing classic histomorphological features, involving the parotid gland of a 17-year-old girl. It was diagnosed as mucoepidermoid carcinoma at a peripheral hospital and was referred to our center. Histologically, it was well circumscribed and composed of lobules, separated by hyalinized stroma. Lobules showed adenosis, foci of acinic cell hyperplasia, and intraductal epithelial proliferation. Immunohistochemistry with p63 highlighted myoepithelial layer around every duct, acinus, and also in foci showing epithelial hyperplasia. There was no evidence of malignancy. Awareness of SPA, a benign rare entity, is essential to avoid misdiagnosing it as other common salivary gland tumors which it may mimic.
硬化性多囊性腺病（SPA）主要是一种大唾液腺疾病。1996年，史密斯等人将其确认为一种独特的形态学实体。据我们所知，英文文献中报道了67例SPA病例。在此，我们描述一例具有典型组织形态学特征的SPA病例，该病例累及一名17岁女孩的腮腺。该病例在外围医院被诊断为黏液表皮样癌，随后转诊至我们中心。组织学上，病变边界清晰，由小叶组成，小叶间为玻璃样变的间质。小叶表现为腺病、腺泡细胞增生灶及导管内上皮增生。p63免疫组化显示每个导管、腺泡周围以及上皮增生灶处均有肌上皮层。无恶性证据。认识到SPA这种罕见的良性实体对于避免将其误诊为可能与之相似的其他常见唾液腺肿瘤至关重要。
