Jiang Zhengyu, Bian Jinjun, Deng Xiaoming
Department of Anesthesiology, Changhai Hospital, Naval Medical University, Shanghai 200433, China. Corresponding author: Deng Xiaoming, Email:
Zhonghua Wei Zhong Bing Ji Jiu Yi Xue. 2019 Jan;31(1):122-125. doi: 10.3760/cma.j.issn.2095-4352.2019.01.025.
Immune metabolism is an emerging highlight in recent years. Revealing the metabolic characteristics of different immune cells in different responses may provide new perspective and direction for the pathogenesis and therapy of many immune-related diseases. Sepsis is a complex systemic inflammation caused by trauma, infection and other pathogenic factors. The immune cells have different metabolic features at different stages of the disease. These metabolic features are also involved in the regulation of immune cell proliferation, differentiation and function. By summarizing and analyzing the relevant literatures of immune cell metabolism and inflammation regulation in recent years, the metabolic regulatory factors of different immune cell subgroups and the related characteristics of immune cell metabolism in patients with sepsis were summarized. The in-depth understanding of the metabolic state in different immune cells, and the pathophysiological mechanism of septic immune disorders, especially the immune paralysis stage, would provide a theoretical basis for the clinical application of immune metabolic therapy.
免疫代谢是近年来新兴的研究热点。揭示不同免疫细胞在不同反应中的代谢特征，可能为许多免疫相关疾病的发病机制和治疗提供新的视角和方向。脓毒症是由创伤、感染等致病因素引起的复杂全身性炎症。免疫细胞在疾病的不同阶段具有不同的代谢特征。这些代谢特征也参与免疫细胞增殖、分化和功能的调节。通过总结和分析近年来免疫细胞代谢与炎症调节的相关文献，总结了脓毒症患者不同免疫细胞亚群的代谢调节因子及免疫细胞代谢的相关特征。深入了解不同免疫细胞的代谢状态以及脓毒症免疫紊乱尤其是免疫麻痹阶段的病理生理机制，将为免疫代谢治疗的临床应用提供理论依据。
