白头翁中环羊毛甾烷型三萜糖苷类细胞毒素。
Cytotoxic 9,19-cycloartane type triterpenoid glycosides from the roots of Actaea dahurica.
机构信息
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
State Key Laboratory of Bioactive Substance and Function of Natural Medicines, Institute of Materia Medica, Chinese Academy of Medical Sciences and Peking Union Medical College, Beijing 100050, People's Republic of China.
出版信息
Phytochemistry. 2019 Apr;160:48-55. doi: 10.1016/j.phytochem.2019.01.004. Epub 2019 Jan 29.
Ten undescribed 9,19-cycloartane type triterpenoid glycosides (cimdahxynoside A-J) and five known analogues were obtained from the phytochemical research on the roots of Actaea dahurica (syn. Cimicifuga dahurica). All compounds were characterised by spectroscopic experiments, chemical method and X-ray Single-crystal diffraction analysis. Cimdahxynoside A represented the first X-ray crystallography of 9,19-cycloartane type triterpenoid diglycoside. The cytotoxicity of all compounds were tested against five human cancer cell lines. Cimdahxynoside F showed significant cytotoxicity, with IC values between 6.6 and 9.9 μM.
从兴安升麻（Actaea dahurica）（又名：关苍术 Cimicifuga dahurica）的植物化学研究中获得了 10 种未描述的 9,19-环阿尔廷型三萜皂苷（cimdahxynoside A-J）和 5 种已知类似物。所有化合物均通过光谱实验、化学方法和 X 射线单晶衍射分析进行了表征。cimdahxynoside A 代表了 9,19-环阿尔廷型三萜双糖苷的首次 X 射线晶体学研究。所有化合物的细胞毒性均针对五种人类癌细胞系进行了测试。cimdahxynoside F 表现出显著的细胞毒性，IC 值在 6.6 到 9.9 μM 之间。
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