One major area that has gathered public attention in relation to climate change is health risks. Studies into risk perceptions have acknowledged differences between public and expert knowledge. What is less known is how perceptions of climate change related health risk vary between the public and health experts and how these differentiated perceptions are shaped and modified by everyday complex climate change narratives from multiple actors, and contextual ecologies of social and physical spaces. A concurrent mixed-methods approach was used to elucidate climate change knowledge and awareness of climate-related health risks among health experts and the public. Qualitative and quantitative data were collected on community members (n = 927) and health experts (n = 99) in Savelugu-Nanton and Ada East Districts in Ghana. The results showed that both groups were likely to report climate change-related health concerns, of which disease was the top concern. However, differences exist in public and experts' perceptions of climate change health linkage. Community members were less likely to link climate change to health risks compared with health experts (OR = 0.02, p ≤ 0.000). The contrasting climate change health risk perceptions between health experts and the public adds to the literature on the health dimensions of global environmental change. The findings from this study highlight limited knowledge about climate change health related risks among the public. Hence, in building sustainable communities in light of persistent climate change impacts, it is crucial to improve climate change adaptation by implementing climate change sensitization programs. In addition, health infrastructure, decision-making and management should be strengthened for effective response to emerging climate-health risks in Ghana and similar contexts.