Stem Cell Research Center, Tabriz University of Medical Sciences, Tabriz, Iran; Student Research Committee, Tabriz University of Medical Sciences, Tabriz, Iran.
Endocrine Research Center, Tabriz University of Medical Sciences, Tabriz, Iran.
Biosens Bioelectron. 2019 Mar 15;129:164-174. doi: 10.1016/j.bios.2019.01.008. Epub 2019 Jan 15.
Biosensors have been commonly used in biomedical diagnostic tools in recent years, because of a wide range of application, such as point-of-care monitoring of treatment and disease progression, drug discovery, commonly use food control, environmental monitoring and biomedical research. Additionally, development of DNA biosensors has been increased enormously over the past few years as confirmed by the large number of scientific publications in this field. A wide range of techniques can be used for the development of DNA biosensors, such as DNA nano-machines and various signal amplification strategies. This article selectively reviews the recent advances in DNA base biosensors with various signal amplification strategies for detection of cancer DNA and microRNA, infectious microorganisms, and toxic metal ions.
近年来，生物传感器已广泛应用于生物医学诊断工具中，因为其应用广泛，如治疗和疾病进展的即时监测、药物发现、常用食品控制、环境监测和生物医学研究。此外，正如该领域大量科学出版物所证实的那样，过去几年中 DNA 生物传感器的发展已经大大增加。可以使用多种技术来开发 DNA 生物传感器，例如 DNA 纳米机器和各种信号放大策略。本文选择性地综述了具有各种信号放大策略的 DNA 碱基生物传感器在检测癌症 DNA 和 microRNA、传染性微生物和有毒金属离子方面的最新进展。
