脑源性神经营养因子与首发和慢性精神分裂症的认知障碍有关。
Brain-derived neurotrophic factor is associated with cognitive impairments in first-episode and chronic schizophrenia.
机构信息
Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Mental Disorders, Changsha, China; National Technology Institute on Mental Disorders, Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China.
Department of Psychiatry, The Second Xiangya Hospital of Central South University, Changsha, Hunan, China; Mental Health Institute, The Second Xiangya Hospital, Central South University, Changsha, China; National Clinical Research Center on Mental Disorders, Changsha, China; National Technology Institute on Mental Disorders, Changsha, China; Hunan Key Laboratory of Psychiatry and Mental Health, Changsha, China.
出版信息
Psychiatry Res. 2019 Mar;273:528-536. doi: 10.1016/j.psychres.2019.01.051. Epub 2019 Jan 18.
Brain-derived neurotrophic factor (BDNF) may be related to the pathophysiology of schizophrenia. This study aims to examine the relation between plasma BDNF levels and the cognition of patients with schizophrenia. We recruited 31 patients with chronic schizophrenia, 34 first-episode patients, and 35 healthy control subjects. We examined the MATRICS Consensus Cognitive Battery (MCCB) and the plasma BDNF levels in all groups. The schizophrenic symptoms were assessed using the positive and negative syndrome scale. The BDNF levels of schizophrenic patients were remarkably lower than those of the controls. The cognitive MCCB global composite scores and part index scores of schizophrenic patients were remarkably lower than those of the controls. Moreover, remarkable correlations were observed between BDNF levels and partial cognitive dimensions, such as visual learning, memory, and processing speed. Therefore, BDNF may be involved in the pathophysiology and cognitive impairment of schizophrenia.
脑源性神经营养因子（BDNF）可能与精神分裂症的病理生理学有关。本研究旨在探讨精神分裂症患者血浆 BDNF 水平与认知功能的关系。我们招募了 31 名慢性精神分裂症患者、34 名首发患者和 35 名健康对照组。我们检查了所有组的 MATRICS 共识认知电池（MCCB）和血浆 BDNF 水平。使用阳性和阴性症状量表评估精神分裂症症状。精神分裂症患者的 BDNF 水平明显低于对照组。精神分裂症患者的 MCCB 认知综合评分和部分指数评分明显低于对照组。此外，BDNF 水平与部分认知维度（如视觉学习、记忆和处理速度）之间存在显著相关性。因此，BDNF 可能参与了精神分裂症的病理生理学和认知障碍。
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