Balseiro Ana, Perez Valentin, Juste Ramon A
Centro de Biotecnología Animal, Servicio Regional de Investigación y Desarrollo Agroalimentario (SERIDA), 33394 Gijón, Asturias, Spain.
Departamento de Sanidad Animal, Instituto de Ganadería de Montaña (CSIC-ULE), Facultad de Veterinaria, Universidad de León, 24071 León, Spain.
Comp Immunol Microbiol Infect Dis. 2019 Feb;62:88-100. doi: 10.1016/j.cimid.2018.12.001. Epub 2018 Dec 15.
Crohn's disease and ulcerative colitis in humans and paratuberculosis in domestic and wild ruminants can be defined as chronic regional intestinal inflammatory diseases (CRIID). This review is a literature overview on these diseases in humans, non-human primates, dogs, cats, rabbits, equids and ruminants with a focus on pathological and microbiological features aimed identifying common characteristics that could lead to a unified pathological classification for a better understanding of their mechanisms and causes. The result is a framework of inflammatory forms throughout the different species indicative of common mechanisms of the slow infection type characterized by a time course varying from weeks to months or even years, and where the inflammatory component would be more prominent in the intestinal interphase between host and environment and be morphologically characterized by an infiltrate ranging from lymphoplasmacytic to histiocytic. This should provide new insights for causation demonstration and therapeutic approaches in human IBD.
人类的克罗恩病和溃疡性结肠炎以及家养和野生反刍动物的副结核病可被定义为慢性局灶性肠道炎症性疾病（CRIID）。本综述是对人类、非人灵长类动物、犬、猫、兔、马和反刍动物中这些疾病的文献概述，重点关注病理和微生物学特征，旨在识别可能导致统一病理分类的共同特征，以便更好地理解其机制和病因。结果是一个贯穿不同物种的炎症形式框架，表明慢感染类型的共同机制，其病程从数周、数月甚至数年不等，且炎症成分在宿主与环境之间的肠道界面更为突出，形态学特征为从淋巴细胞浆细胞浸润到组织细胞浸润。这应为人类炎症性肠病的病因论证和治疗方法提供新的见解。
