采用串联质谱分子网络对荔枝果肉中的酚类物质进行综合结构表征。
Comprehensive structural characterization of phenolics in litchi pulp using tandem mass spectral molecular networking.
机构信息
Zhejiang Provincial Key Laboratory of Horticultural Plant Integrative Biology, Zhejiang University, Zijingang Campus, Hangzhou 310058, China; Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
Department of Chemistry, National Taiwan University, Taipei 10617, Taiwan.
出版信息
Food Chem. 2019 Jun 1;282:9-17. doi: 10.1016/j.foodchem.2019.01.001. Epub 2019 Jan 3.
Phenolic compounds are a large class of plant secondary metabolites with various health-promoting effects, and are known for their structural diversity. Therefore, high efficiency characterization of phenolic profiles is of key importance in identifying their potential bioactivity. In the present study, Global Natural Products Social (GNPS) Molecular Networking was applied to trace the phenolic compounds in plants, which allowed the characterization of 9 procyanidins and 11 flavonoid glycosides (di-, tri-, or tetra-saccharides of kaempferol, quercetin, isorhamnetin and myricetin) in litchi pulp extracts. Six compounds were reported for the first time in litchi pulp. In addition, quercetin-3-O-rutinoside-(1 → 2)-O-rhamnoside, the most abundant flavonoid glycoside in litchi pulp, was proved to have considerable α-glucosidase inhibitory activity, illustrating the anti-diabetic potential of phenolic-rich litchi pulp extracts.
酚类化合物是一大类植物次生代谢产物，具有多种促进健康的作用，其结构多样性也为人所知。因此，高效地描述酚类成分的特征对于确定其潜在的生物活性至关重要。在本研究中，应用全球天然产物社会分子网络（GNPS Molecular Networking）来追踪植物中的酚类化合物，这使得能够对荔枝果肉提取物中的 9 种原花青素和 11 种类黄酮糖苷（山柰酚、槲皮素、异鼠李素和杨梅素的二糖、三糖或四糖）进行特征描述。其中 6 种化合物是首次在荔枝果肉中被发现。此外，荔枝果肉中含量最丰富的类黄酮糖苷槲皮素-3-O-鼠李糖苷-(1 → 2)-O-阿拉伯糖苷被证明具有相当的α-葡萄糖苷酶抑制活性，这表明富含酚类的荔枝果肉提取物具有抗糖尿病的潜力。
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