前额叶皮层中的多巴胺与认知控制。

Dopamine and Cognitive Control in Prefrontal Cortex.

机构信息

Animal Physiology Unit, Institute of Neurobiology, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany; Present address: Cold Spring Harbor Laboratory, 1 Bungtown Road, Cold Spring Harbor, NY 11724, USA.

Animal Physiology Unit, Institute of Neurobiology, University of Tübingen, Auf der Morgenstelle 28, 72076 Tübingen, Germany.

出版信息

Trends Cogn Sci. 2019 Mar;23(3):213-234. doi: 10.1016/j.tics.2018.12.006. Epub 2019 Jan 31.

DOI:10.1016/j.tics.2018.12.006

PMID:30711326

Abstract

Cognitive control, the ability to orchestrate behavior in accord with our goals, depends on the prefrontal cortex. These cognitive functions are heavily influenced by the neuromodulator dopamine. We review here recent insights exploring the influence of dopamine on neuronal response properties in prefrontal cortex (PFC) during ongoing behaviors in primates. This review suggests three major computational roles of dopamine in cognitive control: (i) gating sensory input, (ii) maintaining and manipulating working memory contents, and (iii) relaying motor commands. For each of these roles, we propose a neuronal microcircuit based on known mechanisms of action of dopamine in PFC, which are corroborated by computational network models. This conceptual approach accounts for the various roles of dopamine in prefrontal executive functioning.

摘要

认知控制，即根据我们的目标协调行为的能力，依赖于前额叶皮层。这些认知功能受到神经调质多巴胺的强烈影响。我们在这里回顾了最近的研究进展，探讨了多巴胺对灵长类动物在进行中行为时前额叶皮层（PFC）神经元反应特性的影响。该综述提出了多巴胺在认知控制中的三个主要计算作用：（i）门控感觉输入，（ii）维持和操作工作记忆内容，以及（iii）传递运动命令。对于每一个作用，我们基于多巴胺在 PFC 中的已知作用机制，提出了一个神经元微电路，该模型得到了计算网络模型的支持。这种概念方法解释了多巴胺在前额叶执行功能中的各种作用。