UMR BIPAR, INRA, Ecole Nationale Vétérinaire d'Alfort, ANSES, Université Paris-Est, Maisons-Alfort, France.
SaBio, Instituto de Investigación en Recursos Cinegéticos IREC (CSIC-UCLM-JCCM), Ciudad Real, Spain.
Trends Parasitol. 2019 Apr;35(4):316-328. doi: 10.1016/j.pt.2019.01.006. Epub 2019 Jan 30.
The first tick genome published in 2016 provided an invaluable tool for studying the molecular basis of tick-pathogen interactions. Metabolism is a key element in host-pathogen interactions. However, our knowledge of tick-pathogen metabolic interactions is very limited. Recently, a systems biology approach, using omics datasets, has revealed that tick-borne pathogen infection induces transcriptional reprograming affecting several metabolic pathways in ticks, facilitating infection, multiplication, and transmission. Results suggest that the response of tick cells to tick-borne pathogens is associated with tolerance to infection. Here we review our current understanding of the modulation of tick metabolism by tick-borne pathogens, with a focus on the model intracellular bacterium Anaplasma phagocytophilum.
2016 年发表的第一份蜱基因组为研究蜱与病原体相互作用的分子基础提供了宝贵的工具。代谢是宿主-病原体相互作用的关键因素。然而，我们对蜱-病原体代谢相互作用的了解非常有限。最近，一种使用组学数据集的系统生物学方法表明，蜱传病原体感染诱导转录重编程，影响蜱中的几种代谢途径，从而促进感染、增殖和传播。结果表明，蜱细胞对蜱传病原体的反应与对感染的耐受有关。在这里，我们综述了我们目前对蜱传病原体对蜱代谢的调节的理解，重点介绍了模型细胞内细菌嗜吞噬细胞无形体。
