Department of Periodontics, School of Dentistry, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA.
Department of Libraries, Louisiana State University Health Sciences Center, 1100 Florida Avenue, New Orleans, LA 70119, USA.
J Craniomaxillofac Surg. 2019 Mar;47(3):443-453. doi: 10.1016/j.jcms.2019.01.012. Epub 2019 Jan 17.
This systematic review aimed at assessing the effects of PRGF in new bone formation, soft tissue healing and post-operative pain and swelling in sites that underwent ridge preservation, ridge augmentation and maxillary sinus augmentation procedures.
A comprehensive literature search employing seven databases was conducted by two independent reviewers. Only randomized and non-randomized controlled clinical trials using PRGF alone or in combination with bone grafting materials were selected.
Overall, 919 studies were identified, of which a total of 8 articles were included in the qualitative analysis. Two of the selected studies reported on ridge preservation, one on ridge augmentation and five on maxillary sinus augmentation. Positive results were recorded for soft tissue healing and post-operative pain and swelling following these procedures. However, outcomes of PRGF on new bone formation post extraction and on maxillary sinus augmentation when combined with other biomaterials were conflicting. Meta-analysis could not be conducted for any variables due to the heterogeneity of selected studies.
Limited evidence exists on the effects of PRGF in different intraoral bone grafting procedures, with some benefit reported on soft tissue healing and post-operative symptomatology. As this platelet concentrate is commonly used in clinical practice, further research is needed to fully assess its clinical indications and effectiveness.
本系统评价旨在评估 PRGF 在接受牙槽嵴保存术、牙槽嵴增量术和上颌窦提升术的部位的新骨形成、软组织愈合以及术后疼痛和肿胀方面的效果。
两位独立评审员进行了一次全面的文献检索，使用了七个数据库。仅选择了单独使用 PRGF 或与骨移植材料联合使用的随机和非随机对照临床试验。
总共确定了 919 项研究，其中共有 8 篇文章被纳入定性分析。所选研究中有两项报告了牙槽嵴保存术，一项报告了牙槽嵴增量术，五篇报告了上颌窦提升术。这些手术的软组织愈合和术后疼痛肿胀均取得了积极的结果。然而，PRGF 对拔牙后新骨形成和与其他生物材料联合使用在上颌窦提升术中的效果存在争议。由于所选研究的异质性，任何变量都无法进行荟萃分析。
关于 PRGF 在不同的口腔内骨移植手术中的效果，证据有限，有一些益处报告在软组织愈合和术后症状方面。由于这种血小板浓缩物在临床实践中常用，需要进一步的研究来全面评估其临床适应证和有效性。
