Institute of Stomatology & Research Center of Dental and Craniofacial Implants, School and Hospital of Stomatology, Fujian Medical University, Fuzhou, Fujian, China.
Department of Oral and Maxillofacial Surgery, College of Dentistry, Ibb University, Sanaa, Yemen.
BMC Oral Health. 2024 Oct 24;24(1):1275. doi: 10.1186/s12903-024-04952-w.
Concentrated Growth Factor (CGF) is a highly effective biomaterial known for its ability to promote tissue regeneration. While it's been studied extensively in intraoral procedures and bone grafting, its benefits in maxillary sinus lifting lack substantial evidence. This review aimed to evaluate CGF's effectiveness in maxillary sinus augmentation, focusing on clinical, radiographic, and histological outcomes.A comprehensive literature search was conducted across PubMed, Scopus, Web of Science, Google Scholar, and Cochrane Library databases using specific mesh terms and keywords and adhered to PRISMA guidelines. Studies up to March 2024 involving transcrestal or lateral maxillary sinus floor elevation with CGF, either alone or in combination with grafting materials, were included.Out of 783 publications, 13 studies met the eligibility criteria. The review assessed CGF's role in minimizing postoperative complications, enhancing new bone formation, and improving implant survival. Despite data variability among studies, the majority reported that CGF positively influenced maxillary sinus augmentation outcomes.While more robust randomized clinical trials are required to draw definitive conclusions, initial results are promising, and the findings suggest that CGF utilization in maxillary sinus augmentation seems to enhance clinical outcomes by promoting vascularization and regeneration at the surgical sites and improving both the quality and quantity of newly formed sinus bone. Furthermore, it exhibits potential for improving postoperative sequelae and achieving high implant survival rates.
浓缩生长因子 (CGF) 是一种高效的生物材料，以促进组织再生的能力而闻名。虽然它在口腔内手术和骨移植中得到了广泛的研究，但在上颌窦提升中其益处缺乏大量证据。本次综述旨在评估 CGF 在上颌窦扩增中的有效性，重点关注临床、放射影像学和组织学结果。
我们在 PubMed、Scopus、Web of Science、Google Scholar 和 Cochrane Library 数据库中使用特定的主题词和关键词进行了全面的文献检索，并遵循 PRISMA 指南。纳入了截至 2024 年 3 月涉及单独使用或与移植物材料联合使用 CGF 的经牙槽嵴或上颌窦侧壁提升的研究。
在 783 篇出版物中，有 13 项研究符合入选标准。本次综述评估了 CGF 在减少术后并发症、促进新骨形成和提高种植体存活率方面的作用。尽管研究之间的数据存在差异，但大多数研究报告称 CGF 对上颌窦扩增结果有积极影响。
虽然需要进行更多的、更有说服力的随机临床试验才能得出明确的结论，但初步结果是有希望的，研究结果表明，CGF 在上颌窦扩增中的应用似乎通过促进手术部位的血管生成和再生，以及改善新形成的窦骨的质量和数量，从而增强了临床结果。此外，它还有望改善术后后遗症并实现高种植体存活率。
