Department of Respiratory Medicine, The Second Hospital of Jilin University, Changchun, Jilin 130021, China.
Department of Oncology and Hematology, The Second Hospital of Jilin University, Changchun, Jilin 130021, China.
Life Sci. 2019 Mar 1;220:177-185. doi: 10.1016/j.lfs.2019.01.055. Epub 2019 Jan 31.
CircRNAs are a class of competitive, endogenous, non-coding RNAs with closed-loop structures. High-throughput sequencing indicates that circRNAs are ubiquitously expressed in many eukaryotes. Biological functions of circRNAs include interaction with proteins and regulation of gene transcription, translation, and miRNA sponge activity. These functions suggest that circRNAs may be useful as novel biomarkers for disease diagnosis and prognosis. Lung cancer is known worldwide as the most common malignant tumor. It is also the main cause of cancer-related death. In recent years, it has become increasingly evident that circRNAs are involved in the proliferation, migration, and invasion of lung cancer cells. Differentially expressed circRNAs may be used as non-invasive diagnostic and prognostic markers for lung cancer. Therefore, they are considered a research hotspot for lung cancer studies. This article is a systematic review of mechanisms underlying the action, diagnosis, clinical aspects, and drug resistance of circRNAs in lung cancer.
CircRNAs 是一类具有封闭环结构的竞争性、内源性、非编码 RNA。高通量测序表明， circRNAs 在许多真核生物中广泛表达。circRNAs 的生物学功能包括与蛋白质相互作用和调节基因转录、翻译和 miRNA 海绵活性。这些功能表明，circRNAs 可能作为疾病诊断和预后的新型生物标志物具有潜在的应用价值。肺癌是世界范围内最常见的恶性肿瘤，也是癌症相关死亡的主要原因。近年来，越来越明显的是，circRNAs 参与了肺癌细胞的增殖、迁移和侵袭。差异表达的 circRNAs 可作为非侵入性诊断和预后标志物用于肺癌。因此，它们被认为是肺癌研究的一个热点。本文对 circRNAs 在肺癌中的作用机制、诊断、临床方面和耐药性进行了系统综述。
