Rubio Carlos A, Schmidt Peter T
Gastrointestinal and Liver Research Laboratory, Department of Pathology, Karolinska Institute and University Hospital, Stockholm, Sweden
Department of Medicine Solna, Center for Digestive Diseases, Karolinska Institute and University Hospital, Stockholm, Sweden.
Anticancer Res. 2019 Feb;39(2):833-838. doi: 10.21873/anticanres.13182.
Colonic crypts with normal epithelial lining exhibiting corrupted shapes (NECS) have been previously found beneath the adenomatous tissue of polypoid conventional adenomas, in both rats and humans.
To assess the frequency of NECS in non-polypoid colonic flat adenomas (FAs) and lateral-spreading adenomas (LSAs).
Histological hematoxylin and eosin-stained sections from 51 non-polypoid colonic adenomas were scrutinized over a 10-mm field of vision (FOV). FAs were regarded lesions encompassed within the FOV and LSAs as those surpassing that limit. The NECS/mm ratio was calculated in individual lesions as the number of NECS beneath the adenomatous tissue, divided by the length (mm) of the FA and LSA.
Out of the 51 non-polypoid adenomas, 27 were FAs and the remaining 24 LSAs. All 51 non-polypoid lesions were tubular adenomas. The mean number of NECS in FAs was 6.29 (range=2-10) and in LSAs was 15.29 (range=7-41) (p<0.05). On the other hand, the mean NECS/mm ratio in FAs was 0.94 (range=0.50-2.00) and in LSAs was 0.92 (range=0.40-2.93). Thus, no essential differences in the number of NECS/mm was found between FA and LSA.
The accretion of NECS below the neoplastic canopy of FA and LSA contrasts with the rare occurrence of NECS in normal colonic mucosa. This finding emerges as a previously unaddressed major event, an event that might play an important role in the histogenesis of non-polypoid adenomas of the colon.
先前在大鼠和人类的息肉样传统腺瘤的腺瘤组织下方均发现了具有正常上皮内衬但形状异常的结肠隐窝（NECS）。
评估非息肉样结肠扁平腺瘤（FAs）和侧向扩散腺瘤（LSAs）中NECS的发生率。
对51例非息肉样结肠腺瘤的苏木精和伊红染色组织切片在10毫米视野（FOV）内进行仔细检查。FAs被视为包含在FOV内的病变，而LSAs则是超过该界限的病变。计算单个病变中的NECS/mm比率，即腺瘤组织下方的NECS数量除以FAs和LSAs的长度（毫米）。
在这51例非息肉样腺瘤中，27例为FAs，其余24例为LSAs。所有51例非息肉样病变均为管状腺瘤。FAs中NECS的平均数量为6.29（范围=2-10），LSAs中为15.29（范围=7-41）（p<0.05）。另一方面，FAs中NECS/mm的平均比率为0.94（范围=0.50-2.00），LSAs中为0.92（范围=0.40-2.93）。因此，FAs和LSAs之间在NECS/mm数量上未发现本质差异。
FAs和LSAs肿瘤覆盖下的NECS增加与正常结肠黏膜中罕见的NECS形成对比。这一发现是一个先前未被关注的重要事件，可能在结肠非息肉样腺瘤的组织发生中起重要作用。
