1 Department of Otolaryngology - Head and Neck Surgery, National Defense Medical Center, Tri-Service General Hospital, Taipei.
2 Department of Medical Research, National Defense Medical Center, Tri-Service General Hospital, Taipei.
Diab Vasc Dis Res. 2019 Jul;16(4):324-327. doi: 10.1177/1479164119826292. Epub 2019 Feb 2.
The risk of sudden sensorineural hearing loss associated with metformin use in patients with diabetes mellitus has not been fully examined.
It is a retrospective matched-cohort study.
We examined the medical records of patients with diabetes mellitus over 18 years old in Taiwan's National Health Insurance Research Database for the period between 1 January 2000 and 31 December 2013, to establish matched cohorts (14,109 with and 42,327 without metformin use) at a ratio of 1:3 by sex, age and index year.
We used a Cox regression hazard model to identify risk factors of sudden sensorineural hearing loss during 14 years of follow-up, and the results indicate that a significantly lower percentage of diabetes mellitus patients with metformin use ( = 0.033) developed sudden sensorineural hearing loss compared with those without metformin use (0.21%, 29/14,109 vs 0.32%, 136/42,327). After adjustment for age and other variables [adjusted hazard ratio: 0.630 (95% confidence interval: 0.422-0.941, = 0.024)], this study also demonstrated that metformin use appeared to reduce the risk of developing sudden sensorineural hearing loss.
This study demonstrated an association between metformin use and lower incidence of sudden sensorineural hearing loss among patients with diabetes mellitus.
糖尿病患者使用二甲双胍与突发性感觉神经性听力损失的风险尚未得到充分研究。
这是一项回顾性匹配队列研究。
我们在台湾全民健康保险研究数据库中检查了 2000 年 1 月 1 日至 2013 年 12 月 31 日期间年龄超过 18 岁的糖尿病患者的病历，以建立匹配队列（14109 名使用二甲双胍和 42327 名未使用二甲双胍），性别、年龄和索引年份的比例为 1:3。
我们使用 Cox 回归风险模型来确定 14 年随访期间突发性感觉神经性听力损失的危险因素，结果表明，使用二甲双胍的糖尿病患者突发性感觉神经性听力损失的比例明显较低（=0.033），而未使用二甲双胍的患者（0.21%，29/14109 与 0.32%，136/42327）。调整年龄和其他变量后[调整后的风险比：0.630（95%置信区间：0.422-0.941，=0.024)]，本研究还表明，二甲双胍的使用似乎降低了突发性感觉神经性听力损失的风险。
本研究表明，糖尿病患者使用二甲双胍与突发性感觉神经性听力损失的发生率较低之间存在关联。
