Department of Infectious Disease, Zanjan University of Medical Sciences, Zanjan, Iran.
Critical Care Nursing, Zanjan University of Medical Sciences, Zanjan, Iran.
J Natl Med Assoc. 2020 Feb;112(1):91-96. doi: 10.1016/j.jnma.2018.12.001. Epub 2019 Feb 1.
Infection by Primate erythroparvovirus 1, generally known Parvovirus B19, is highly prevalent worldwide. Although infection by this virus will not be clinically problematic in most cases, new infections during pregnancy could result in serious repercussions in the fetus. Serologic and PCR-based methods are among the available approaches for diagnosis of Parvovirus B19 infection. In this regard, the present study is aimed to investigate the frequency of Parvovirus B19 infection by these two techniques in pregnant women of Zanjan.
In this cross sectional-descriptive study, 110 pregnant women referring to Mousavi hospital in Zanjan during one year were evaluated in terms of serologic and Real-Time PCR test results in search for Parvovirus B19 infection. The rate of positive IgG and IgM were determined in women and the Real-Time PCR results were reported.
Overall, 18.2% of participants were above 35 years old and 4.5% of them were younger than 18 years old. 41 (44.1%) and 2 (1.8%) cases had positive anti-Parvovirus B19 IgG and IgM, respectively. Real-Time PCR results were negative in all the studied samples.
Based on the findings of this study, prevalence of acute Parvovirus B19 infection was 0 and 2% based on Real-Time PCR and IgM tests, respectively. About 40% of pregnant women had experienced infection with this virus before.
灵长类细小病毒 1 （通常称为细小病毒 B19）的感染在全球范围内非常普遍。尽管这种病毒的感染在大多数情况下不会对临床造成问题，但在怀孕期间的新感染可能会对胎儿造成严重影响。血清学和基于 PCR 的方法是诊断细小病毒 B19 感染的可用方法之一。在这方面，本研究旨在调查这两种技术在赞詹孕妇中感染细小病毒 B19 的频率。
在这项横断面描述性研究中，对 110 名在赞詹 Mousavi 医院就诊的孕妇进行了评估，检查了他们的血清学和实时 PCR 检测结果，以寻找细小病毒 B19 感染的情况。确定了女性 IgG 和 IgM 的阳性率，并报告了实时 PCR 结果。
总体而言，18.2%的参与者年龄超过 35 岁，4.5%的参与者年龄小于 18 岁。41 例（44.1%）和 2 例（1.8%）分别有抗细小病毒 B19 IgG 和 IgM 阳性。所有研究样本的实时 PCR 结果均为阴性。
根据本研究的结果，基于实时 PCR 和 IgM 检测，急性细小病毒 B19 感染的流行率分别为 0 和 2%。约 40%的孕妇之前曾感染过该病毒。
