Di Stefano L, Carta G, Barnabei R, Tomei E, Toro G, Moscarini M
Università degli Studi de L'Aquila, Clinica Ostetrica e Ginecologica, USSL N. 6.
Minerva Ginecol. 1995 Apr;47(4):121-5.
Parvovirus B19 is a small, heat-stable, single-strained DNA virus (5.5 kb), with 23 nm icosahedral capsid discovered in 1975. Since its discovery, the virus has been shown to be a causative agent of erythema infectiosum (fifth disease). Under specific circumstances it can cause transient aplastic crisis, chronic anemia, arthritis and fetal death. Laboratory diagnosis of recent or past B19 infection usually relies on the demonstration of virus-specific IgM or IgG antibodies in patient's serum. The aim of this study was to evaluate the prevalence of Parvovirus B19 infection among 87 pregnant patients. Our study on anti-B19 antibody prevalence indicates that about 64% of pregnant women in our country lack specific antibodies and are at risk of B19 infection. One intrauterine death was encountered in a patient with specific IgM antibodies. The authors suggest the detection of IgG and IgM anti-B19 antibodies as a routine screening practice during pregnancy.
细小病毒B19是一种小型、热稳定的单链DNA病毒（5.5kb），1975年发现其具有23纳米的二十面体衣壳。自发现以来，该病毒已被证明是传染性红斑（第五病）的病原体。在特定情况下，它可导致短暂性再生障碍危象、慢性贫血、关节炎和胎儿死亡。近期或既往B19感染的实验室诊断通常依赖于在患者血清中检测病毒特异性IgM或IgG抗体。本研究的目的是评估87例孕妇中细小病毒B19感染的患病率。我们关于抗B19抗体患病率的研究表明，我国约64%的孕妇缺乏特异性抗体，有感染B19的风险。1例具有特异性IgM抗体的患者发生了1例宫内死亡。作者建议在孕期将检测IgG和IgM抗B19抗体作为常规筛查措施。
