Kumar Vaibhav, Chahar Puneet, Kajjari Shweta, Rahman Faizia, Bansal Deepak K, Kapadia Junaid Mh
Department of Public Health Dentistry, Terna Dental College, Nerul, Navi Mumbai, Maharashtra, India.
Maulana Azad Institute of Dental Sciences, New Delhi, India.
J Contemp Dent Pract. 2018 Dec 1;19(12):1512-1516.
To comparatively evaluate the status of fluoride in the body with thyroid activity in the pediatric population of endemic fluorosis areas. The present study also attempted to elucidate whether any correlation exists between fluoride and thyroid hormone derangement with delayed tooth eruption.
A total of 400 pediatric subjects were included in the present study. All the patients were divided into two broad groups; groups A and B. Group A included 200 subjects who belonged to the endemic fluorosis area while Group B included remaining 200 subjects, who belonged to the fluorosis non-endemic area. Group B subjects were taken as control. Group A subjects were further divided into two study groups as follows: Group A1: 100 Pediatric subjects with dental fluorosis, and Group A 2: A total of one hundred pediatric subjects without dental fluorosis. Dean's index of fluorosis was calculated in all the patients. Blood samples were collected and were sent to a laboratory for assessment of thyroid hormone levels. All the results were subjected to statistical analysis by Statistical Package for the Social Sciences (SPSS) software.
Mean thyroid stimulating hormone (TSH), water fluoride levels, urine fluoride levels and serum fluoride levels of subjects in group 1 were found to be significantly higher than that of subjects of group 2. Delayed tooth eruption was absent in subjects of group B while it was present in 100 subjects of group A. Thyroid hormone level derangement was seen in 54 percent subjects of group B, while it was seen in 67.5% subjects of group A.
Positive correlation exists between fluorosis and thyroid functional activity. However; the tooth eruption pattern is independent up on the thyroid hormone derangement.
Delayed tooth eruption and alteration in thyroid hormone levels can occur in subjects of the endemic fluoride areas. Therefore, adequate measures should be taken for controlling such adverse effects.
比较评估地方性氟中毒病区儿童群体体内氟含量与甲状腺活性的状况。本研究还试图阐明氟与甲状腺激素紊乱及牙齿萌出延迟之间是否存在关联。
本研究共纳入400名儿科受试者。所有患者被分为两大组：A组和B组。A组包括200名来自地方性氟中毒病区的受试者，而B组包括其余200名来自非氟中毒病区的受试者。B组受试者作为对照。A组受试者进一步分为以下两个研究组：A1组：100名患有氟斑牙的儿科受试者，A2组：总共100名无氟斑牙的儿科受试者。计算所有患者的迪恩氟中毒指数。采集血样并送往实验室评估甲状腺激素水平。所有结果均通过社会科学统计软件包（SPSS）进行统计分析。
发现第1组受试者的平均促甲状腺激素（TSH）、水氟水平、尿氟水平和血清氟水平显著高于第2组受试者。B组受试者无牙齿萌出延迟，而A组有100名受试者存在牙齿萌出延迟。B组54%的受试者出现甲状腺激素水平紊乱，而A组为67.5%。
氟中毒与甲状腺功能活性之间存在正相关。然而，牙齿萌出模式与甲状腺激素紊乱无关。
地方性氟中毒病区的受试者可能出现牙齿萌出延迟和甲状腺激素水平改变。因此，应采取适当措施控制此类不良反应。
