Nautiyal Amit, Mukherjee Anirban, Mitra Deepanjan, Chatterjee Piyali, Roy Anindya
Department of Nuclear Medicine, AMRI Hospitals, Kolkata, West Bengal, India.
Indian J Nucl Med. 2019 Jan-Mar;34(1):19-23. doi: 10.4103/ijnm.IJNM_112_18.
This study aims to compare glomerular filtration rate (GFR) estimated by Gates method using gamma camera (GC) with single plasma sample method (SPSM) in people with normal and abnormal body mass index (BMI) using SPSM as gold standard.
It was single-center prospective study including 60 voluntary kidney donors. Technetium-99m labeled Diethylene Triamine Pentaacetic Acid (Tc-DTPA) was administered intravenous under GC. GFR was calculated using Gates Method. After the scan, the subjects were called again after 180 min of injection of Tc-DTPA. Then, a 3 ml venous blood sample was obtained from the contralateral arm. Russell's formula was used to determine the GFR by SPSM.
Mean GFR calculated by SPSM and Gates' method, was 94.0 ± 15.2 ml/min/1.73 m and 87.3 ± 16 ml/min/1.73 m respectively. Moderate correlation noted between two methods ( = 0.71, < 0.0001). Significant correlation noted between GFR calculated by SPSM and Gates method in people with normal BMI ( = 0.92) with no significant statistical difference ( = 0.8). However, only moderate correlation noted between GFR calculated by SPSM and Gates method in people with BMI outside normal range ( = 0.71) with a significant statistical difference ( = 0.0002).
Gates method of GFR estimation using GC shows significant correlation with plasma sample technique in people with normal BMI. In people with BMI outside normal range, it significantly underestimates GFR.
本研究旨在以单样本血浆法（SPSM）为金标准，比较采用γ相机（GC）的盖茨法估算的肾小球滤过率（GFR）与单样本血浆法在体重指数（BMI）正常和异常人群中的差异。
这是一项单中心前瞻性研究，纳入了60名自愿肾脏捐献者。静脉注射99m锝标记的二乙三胺五乙酸（Tc-DTPA），并在GC下进行操作。采用盖茨法计算GFR。扫描后，在注射Tc-DTPA 180分钟后再次召集受试者。然后，从对侧手臂采集3ml静脉血样。使用拉塞尔公式通过SPSM确定GFR。
SPSM和盖茨法计算的平均GFR分别为94.0±15.2ml/min/1.73m²和87.3±16ml/min/1.73m²。两种方法之间存在中度相关性（r = 0.71，P < 0.0001）。在BMI正常的人群中，SPSM计算的GFR与盖茨法之间存在显著相关性（r = 0.92），无显著统计学差异（P = 0.8）。然而，在BMI超出正常范围的人群中，SPSM计算的GFR与盖茨法之间仅存在中度相关性（r = 0.71），具有显著统计学差异（P = 0.0002）。
使用GC的盖茨法估算GFR在BMI正常的人群中与血浆样本技术显示出显著相关性。在BMI超出正常范围的人群中，它显著低估了GFR。
