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使用市售设备进行类针刺经皮电神经刺激疗法治疗放疗8年后的口干症成功:一例报告

Accupuncture-like transcutaneous electrical nerve stimulation therapy success using a commercially available unit 8 years post-radiation for xerostomia: a case report.

作者信息

Iovoli Austin J, Singh Anurag K

机构信息

Department of Radiation Medicine, Roswell Park Cancer Institute, Buffalo, NY, USA.

出版信息

J Radiother Pract. 2017 Jun;16(2):217-220. doi: 10.1017/S1460396917000024. Epub 2017 May 8.

DOI:10.1017/S1460396917000024
PMID:30713469
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6358275/
Abstract

BACKGROUND

Accupuncture-like transcutaneous electrical nerve stimulation (ALTENS) therapy has been shown in prospective studies to be effective in the treatment of radiation-induced xerostomia. Those studies treated patients within 27 months from end of radiation with ALTENS delivered in the clinic using a Codetron unit. However, that unit is no longer produced and there is limited data on success of ALTENS when delivered at home.

METHODS

A 50-year old man with xerostomia, 8 years post-radiation for T4N1 squamous cell carcinoma of the tonsillar fossa, was given ALTENS with a currently commercially available unit from Girish Surgical. He used the unit at home, 20 minutes daily for 8 weeks.

RESULTS

After 8 weeks of ALTENS therapy the patient saw a reduction in the Self-Reported University of Michigan Xerostomia-Related Quality of Life Scale from 20 to 1.

CONCLUSION

This case report demonstrates (1) the Girish Surgical unit is effective, (2) self-administration of ALTENS in patients who cannot come to clinic regularly may be practical and (3) ALTENS can still offer durable benefit to patients even 8 years after chemoradiation therapy.

摘要

背景

前瞻性研究表明,针刺样经皮电神经刺激(ALTENS)疗法在治疗放射性口干症方面有效。这些研究使用Codetron装置在诊所对放疗结束后27个月内的患者进行ALTENS治疗。然而,该装置已不再生产,关于在家中进行ALTENS治疗成功的数据有限。

方法

一名50岁男性,因扁桃体窝T4N1鳞状细胞癌放疗后8年出现口干症,使用Girish Surgical公司目前市售的装置进行ALTENS治疗。他在家中使用该装置,每天20分钟,持续8周。

结果

经过8周的ALTENS治疗,患者自我报告的密歇根大学口干症相关生活质量量表评分从20降至1。

结论

本病例报告表明:(1)Girish Surgical公司的装置有效;(2)对于无法定期到诊所就诊的患者,自我进行ALTENS治疗可能可行;(3)即使在放化疗治疗8年后,ALTENS仍可为患者带来持久益处。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df24/6358275/e81f6bce34f1/nihms983308f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df24/6358275/e81f6bce34f1/nihms983308f1.jpg
https://cdn.ncbi.nlm.nih.gov/pmc/blobs/df24/6358275/e81f6bce34f1/nihms983308f1.jpg

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本文引用的文献

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Xerostomia health-related quality of life: NRG oncology RTOG 0537.口干症与健康相关的生活质量:肿瘤放射治疗组(NRG)的RTOG 0537研究
Qual Life Res. 2016 Sep;25(9):2323-33. doi: 10.1007/s11136-016-1255-0. Epub 2016 Feb 25.
2
Acupuncture-Like Transcutaneous Electrical Nerve Stimulation Versus Pilocarpine in Treating Radiation-Induced Xerostomia: Results of RTOG 0537 Phase 3 Study.针刺样经皮电神经刺激与毛果芸香碱治疗放射性口干症的比较:RTOG 0537 三期研究结果
Int J Radiat Oncol Biol Phys. 2015 Jun 1;92(2):220-7. doi: 10.1016/j.ijrobp.2015.01.050. Epub 2015 Apr 1.
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Phase 2 results from Radiation Therapy Oncology Group Study 0537: a phase 2/3 study comparing acupuncture-like transcutaneous electrical nerve stimulation versus pilocarpine in treating early radiation-induced xerostomia.
Long-term outcomes of interventions for radiation-induced xerostomia: A review.
放射性口干症干预措施的长期效果:一项综述。
World J Clin Oncol. 2019 Jan 10;10(1):1-13. doi: 10.5306/wjco.v10.i1.1.
放射治疗肿瘤学组研究 0537 的 2 期结果:一项比较经皮电神经刺激(类似针刺)与毛果芸香碱治疗早期放射性口干的 2/3 期研究。
Cancer. 2012 Sep 1;118(17):4244-52. doi: 10.1002/cncr.27382. Epub 2012 Jan 17.
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Radiation-induced xerostomia.放射性口干症。
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Effect of pilocarpine during radiation therapy: results of RTOG 97-09, a phase III randomized study in head and neck cancer patients.毛果芸香碱在放射治疗期间的作用:RTOG 97-09的结果,一项针对头颈癌患者的III期随机研究。
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A Phase I-II study in the use of acupuncture-like transcutaneous nerve stimulation in the treatment of radiation-induced xerostomia in head-and-neck cancer patients treated with radical radiotherapy.一项关于使用类针刺经皮神经刺激治疗接受根治性放疗的头颈癌患者放射性口干的I-II期研究。
Int J Radiat Oncol Biol Phys. 2003 Oct 1;57(2):472-80. doi: 10.1016/s0360-3016(03)00572-8.
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Preserved salivary output and xerostomia-related quality of life in head and neck cancer patients receiving parotid-sparing radiotherapy.接受保留腮腺放疗的头颈癌患者的唾液分泌量及口干相关生活质量的维持情况
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Xerostomia: diagnosis and management.口干症:诊断与治疗
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