Pahlevaninezhad Hamid, Khorasaninejad Mohammadreza, Huang Yao-Wei, Shi Zhujun, Hariri Lida P, Adams David C, Ding Vivien, Zhu Alexander, Qiu Cheng-Wei, Capasso Federico, Suter Melissa J
Harvard Medical School and Massachusetts General Hospital, Boston MA 02114, United States.
John A. Paulson School of Engineering and Applied Science, Harvard University, Cambridge MA 02138, United States.
Nat Photonics. 2018 Sep;12(9):540-547. doi: 10.1038/s41566-018-0224-2. Epub 2018 Jul 30.
Acquisition of high-resolution images from within internal organs using endoscopic optical imaging has numerous clinical applications. However, difficulties associated with optical aberrations and the trade-off between transverse resolution and depth-of-focus significantly limit the scope of applications. Here, we integrate a metalens, with the ability to modify the phase of incident light at sub-wavelength level, into the design of an endoscopic optical coherence tomography catheter (termed nano-optic endoscope) to achieve near diffraction-limited imaging through negating non-chromatic aberrations. Remarkably, the tailored chromatic dispersion of the metalens in the context of spectral interferometry is utilized to maintain high-resolution imaging beyond the input field Rayleigh range, easing the trade-off between transverse resolution and depth-of-focus. We demonstrate endoscopic imaging both in resected human lung specimens and in sheep airways . The combination of the superior resolution and higher imaging depth-of-focus of the nano-optic endoscope will likely increase the clinical utility of endoscopic optical imaging.
使用内镜光学成像从内部器官获取高分辨率图像具有众多临床应用。然而，与光学像差相关的困难以及横向分辨率和焦深之间的权衡显著限制了应用范围。在此，我们将一种能够在亚波长水平改变入射光相位的超构透镜集成到内镜光学相干断层扫描导管（称为纳米光学内窥镜）的设计中，通过消除非色差来实现近衍射极限成像。值得注意的是，在光谱干涉测量中利用超构透镜定制的色散来维持超出输入场瑞利范围的高分辨率成像，缓解了横向分辨率和焦深之间的权衡。我们在切除的人肺标本和绵羊气道中展示了内镜成像。纳米光学内窥镜卓越的分辨率和更高的成像焦深相结合，可能会增加内镜光学成像的临床实用性。
