EaStCHEM School of Chemistry , University of Edinburgh , David Brewster Road , Edinburgh , EH9 3FJ , U.K.
Syngenta , Jealott's Hill International Research Centre , Bracknell , Berkshire RG42 6EX , U.K.
Org Lett. 2019 Feb 15;21(4):993-997. doi: 10.1021/acs.orglett.8b03986. Epub 2019 Feb 4.
A precatalyst activation strategy has been developed for earth-abundant metal catalysis enabled by counterion dissociation and demonstrated through alkene hydroboration. Commercially available iron and cobalt tetrafluoroborate salts were found to catalyze the hydroboration of aryl and alkyl alkenes with good functional group tolerance (Fe, 12 substrates; Co, 13 substrates) with three structurally distinct ligands. Key to this endogenous activation was counterion dissociation to generate fluoride which indirectly activates the precatalyst by reaction with pinacol borane.
发展了一种通过抗衡离子离解实现的丰富地球金属催化的前催化剂激活策略，并通过烯烃加氢硼化反应得到了验证。发现市售的铁和钴四氟硼酸盐盐可以在具有良好官能团耐受性的芳基和烷基烯烃的加氢硼化反应中（Fe，12 个底物；Co，13 个底物）催化反应，使用了三种结构不同的配体。这种内源性激活的关键是抗衡离子离解生成氟离子，氟离子通过与频哪醇硼烷反应间接激活前催化剂。
