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脂肪酸还原酶基因家族的扩张塑造了膜翅目昆虫的信息素通讯。

Expansion of the fatty acyl reductase gene family shaped pheromone communication in Hymenoptera.

机构信息

Institute of Organic Chemistry and Biochemistry of the Czech Academy of Sciences, Prague, Czech Republic.

Department of Biochemistry, Faculty of Science, Charles University, Prague, Czech Republic.

出版信息

Elife. 2019 Feb 4;8:e39231. doi: 10.7554/eLife.39231.

DOI:10.7554/eLife.39231
PMID:30714899
原文链接:https://pmc.ncbi.nlm.nih.gov/articles/PMC6361591/
Abstract

Fatty acyl reductases (FARs) are involved in the biosynthesis of fatty alcohols that serve a range of biological roles. Insects typically harbor numerous FAR gene family members. While some FARs are involved in pheromone biosynthesis, the biological significance of the large number of FARs in insect genomes remains unclear. Using bumble bee (Bombini) FAR expression analysis and functional characterization, hymenopteran FAR gene tree reconstruction, and inspection of transposable elements (TEs) in the genomic environment of FARs, we uncovered a massive expansion of the FAR gene family in Hymenoptera, presumably facilitated by TEs. The expansion occurred in the common ancestor of bumble bees and stingless bees (Meliponini). We found that bumble bee FARs from the expanded FAR-A ortholog group contribute to the species-specific pheromone composition. Our results indicate that expansion and functional diversification of the FAR gene family played a key role in the evolution of pheromone communication in Hymenoptera.

摘要

脂肪酰基还原酶（FARs）参与脂肪醇的生物合成，这些醇在多种生物学过程中发挥作用。昆虫通常拥有众多 FAR 基因家族成员。虽然一些 FAR 参与信息素的生物合成，但昆虫基因组中大量 FAR 的生物学意义仍不清楚。通过对熊蜂（Bombini） FAR 表达分析和功能特征、膜翅目 FAR 基因树重建以及 FAR 基因组环境中转座元件（TEs）的检测，我们发现膜翅目昆虫 FAR 基因家族发生了大规模扩张，这可能是由 TEs 促进的。这种扩张发生在熊蜂和无刺蜂（Meliponini）的共同祖先中。我们发现，来自扩张的 FAR-A 直系同源群的熊蜂 FAR 有助于物种特异性信息素组成。我们的结果表明，FAR 基因家族的扩张和功能多样化在膜翅目昆虫信息素通讯进化中发挥了关键作用。

https://cdn.ncbi.nlm.nih.gov/pmc/blobs/0aa4/6361591/9bf37a6dd278/elife-39231-fig6-figsupp6.jpg
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