Department of Clinical Neuroscience, Karolinska Institutet, Stockholm, Sweden.
Center for Neurology, Academic Specialist Center, Stockholm, Sweden.
J Parkinsons Dis. 2019;9(2):361-367. doi: 10.3233/JPD-181486.
Cerebral small vessel disease (SVD), often manifesting as white matter lesions (WMLs), and Parkinson's disease (PD) are common disorders whose prevalence increases with age. Vascular risk factors contribute to SVD, but their role in PD is less clear.
The study objective was to investigate the frequency and grade of WMLs in PD, and their association with clinical and biochemical parameters.
In total, 100 consecutive patients with available magnetic resonance imaging were included. Vascular risk factors including smoking, hypertension, diabetes type 2, atrial fibrillation, heart insufficiency and hypercholesterolemia were assessed. In 50 patients that had underwent lumbar puncture, cerebrospinal fluid (csf) levels of beta-amyloid1-42, tau and phospho-tau were measured.
WMLs were present in 86 of 100 patients. Increasing WML severity was independently associated with increased age and lower csf beta-amyloid1-42.
In our study, WMLs were very common in patients with PD, and were associated with low levels of csf beta-amyloid1-42. Longitudinal studies would increase understanding of the interplay between WMLs and amyloid pathology in PD.
脑小血管病（SVD）常表现为脑白质病变（WMLs），帕金森病（PD）是常见疾病，其患病率随年龄增长而增加。血管危险因素与 SVD 有关，但在 PD 中的作用尚不清楚。
本研究旨在探讨 PD 患者 WMLs 的频率和严重程度及其与临床和生化参数的关系。
共纳入 100 例有磁共振成像（MRI）结果的连续患者。评估了吸烟、高血压、2 型糖尿病、心房颤动、心力衰竭和高胆固醇血症等血管危险因素。在 50 例行腰椎穿刺的患者中，测量了脑脊液（CSF）中β-淀粉样蛋白 1-42、tau 和磷酸化 tau 的水平。
100 例患者中有 86 例存在 WMLs。WML 严重程度的增加与年龄的增加和 CSF 中β-淀粉样蛋白 1-42 的降低独立相关。
在本研究中，PD 患者的 WMLs 非常常见，与 CSF 中β-淀粉样蛋白 1-42 水平降低有关。纵向研究将增加对 WMLs 和 PD 中淀粉样蛋白病理学之间相互作用的理解。
