Ottawa Hospital Research Institute.
Department of Biochemistry, Microbiology & Immunology, University of Ottawa.
Clin Infect Dis. 2019 Aug 30;69(6):1063-1067. doi: 10.1093/cid/ciz068.
The inability to sample deep-tissue reservoirs in individuals living with human immunodeficiency virus (HIV) has greatly hindered accurate estimates of viral reservoir size and distribution. Animal models and collection of tissues during autopsies of HIV-positive individuals are 2 proposed solutions to this problem. Each, however, has its limitations. In this Viewpoint, we argue that tissue donation following medical assistance in death (MAiD) will form an invaluable resource for the characterization of the viral reservoir in the context of current HIV cure research. In support, we discuss a recent instance in which an individual living with HIV chose to donate their body/tissues to HIV research prior to undergoing MAiD at our institution. Going forward, we hope this will help provide support to individuals in their decisions around tissue donation following MAiD, while highlighting how healthcare providers, by complying with such wishes, can affect patient satisfaction in the last days of life.
无法在携带人类免疫缺陷病毒 (HIV) 的个体中取样深部组织储库，极大地阻碍了对病毒储库大小和分布的准确估计。动物模型和对 HIV 阳性个体尸检时采集组织是解决这个问题的 2 种方案。然而，每种方案都有其局限性。在本观点中，我们认为，在医疗辅助死亡（MAiD）后进行组织捐赠将成为当前 HIV 治愈研究中描述病毒储库的宝贵资源。为此，我们讨论了最近在我们机构接受 MAiD 之前，一名携带 HIV 的个体选择将其身体/组织捐赠给 HIV 研究的情况。展望未来，我们希望这将有助于在 MAiD 后进行组织捐赠方面为个人提供支持，同时强调医疗保健提供者如何通过遵守这些意愿来影响生命最后几天的患者满意度。
