BACKGROUND: Power-assisted liposuction and lipofilling (PALL) is a simple and reproducible surgical technique for large volume fat grafting. OBJECTIVES: The authors share their 7-year experience with their large-volume fat transfer technique, PALL. METHODS: A total of 417 patients who underwent PALL-related surgeries involving the breast and buttock were evaluated in a retrospective study. Liposculpting and fat harvesting were performed with power-assisted liposuction. Fat was transferred with simultaneous power-assisted vibration and tunnelization to provoke expansion of the recipient site. Following lipofilling, additional external vibration of the recipient site was performed to enhance diffusion of the injected fat. RESULTS: Liposuction volumes up to 5000 mL were recorded, and injection volumes ranged from 300 to 900 mL per side for each session. Operating times ranged from 45 to 120 minutes. Patients were followed-up for 1 to 4 years. No major complications were recorded. CONCLUSIONS: PALL is an efficient, safe, and reproducible procedure with myriad applications in aesthetic and reconstructive surgery. UNLABELLED: Level of Evidence: 4.