Kawamura M, Kawano Y, Yoshida K, Imanishi M, Akabane S, Matsushima Y, Kuramochi M, Shimamoto K, Yamamoto K, Ito K
Division of Hypertension and Nephrology, National Cardiovascular Center, Osaka, Japan.
J Hypertens Suppl. 1988 Dec;6(4):S508-10. doi: 10.1097/00004872-198812040-00160.
We measured components of the cerebrospinal fluid renin-angiotensin system from patients with essential hypertension under different dietary sodium intakes. The cerebrospinal fluid concentration of angiotensin II (Ang II) from the patients on a normal-sodium diet was 1.36 +/- 0.41 fmol/ml (n = 5). Neither the inactive nor the active form of renin was detected by the enzymatic activity or by the immunoreactivity, whereas angiotensinogen was detected (38.6 +/- 3.1 pmol/ml, n = 5). The Ang II level remained unchanged even after incubation of the cerebrospinal fluid at 37 degrees C for 3 h. Further, when authentic Ang II was added to the cerebrospinal fluid followed by incubation for 3 h at 37 degrees C, more than 90% of the added Ang II remained unchanged. Thus, the cerebrospinal fluid Ang II level may be reflected by the activity of the brain Ang II-forming system, as it was not affected by the cerebrospinal fluid constituents. The circulating renin-angiotensin system was stimulated by sodium depletion, and the cerebrospinal fluid concentration of Ang II also increased significantly. Sodium depletion may stimulate the brain Ang-II forming system, as it does the circulating renin-angiotensin system.
我们测量了不同饮食钠摄入量下原发性高血压患者脑脊液肾素 - 血管紧张素系统的各组分。正常钠饮食患者的脑脊液中血管紧张素II（Ang II）浓度为1.36±0.41 fmol/ml（n = 5）。通过酶活性或免疫反应性均未检测到肾素的无活性形式或活性形式，而检测到了血管紧张素原（38.6±3.1 pmol/ml，n = 5）。即使将脑脊液在37℃孵育3小时后，Ang II水平仍保持不变。此外，当将 authentic Ang II 添加到脑脊液中并在37℃孵育3小时后，超过90% 添加的Ang II保持不变。因此，脑脊液Ang II水平可能由脑Ang II生成系统的活性反映，因为它不受脑脊液成分的影响。循环肾素 - 血管紧张素系统受到钠耗竭的刺激，脑脊液中Ang II浓度也显著增加。钠耗竭可能刺激脑Ang-II生成系统，就像它刺激循环肾素 - 血管紧张素系统一样。 （注：原文中“authentic Ang II”表述有误，推测可能是“人工合成的Ang II”之类的意思，这里按原样翻译）
