Burgess E D, Keane P M, Watanabe M
Department of Medicine, University of Calgary, Alberta, Canada.
J Hypertens Suppl. 1988 Dec;6(4):S85-7. doi: 10.1097/00004872-198812040-00023.
Sodium sensitivity in subjects with high-renin hypertension has been associated with non-modulation of cardiovascular and biochemical responses to alteration in sodium intake. Using the percentage suppression of plasma renin activity in response to an increase in dietary sodium intake, high-renin hypertensive subjects were categorized in two groups. In association with the increase in sodium intake, modulators showed greater than 58% suppression of plasma renin activity, and significant reductions in mean arterial pressure, plasma aldosterone, norepinephrine and serum calcium concentration. Non-modulators had no significant change in plasma renin activity, mean arterial blood pressure, plasma aldosterone, norepinephrine or serum calcium concentration. The blood pressure response to an increase in dietary sodium intake may be a composite of responses of the renin-angiotensin-aldosterone axis, the adrenergic nervous system and calcium regulatory system.
高肾素性高血压患者的钠敏感性与钠摄入量改变时心血管和生化反应未受调节有关。根据饮食中钠摄入量增加时血浆肾素活性的抑制百分比，将高肾素性高血压患者分为两组。随着钠摄入量的增加，调节者的血浆肾素活性抑制率大于58%，平均动脉压、血浆醛固酮、去甲肾上腺素和血清钙浓度显著降低。非调节者的血浆肾素活性、平均动脉血压、血浆醛固酮、去甲肾上腺素或血清钙浓度无显著变化。饮食中钠摄入量增加时的血压反应可能是肾素-血管紧张素-醛固酮轴、肾上腺素能神经系统和钙调节系统反应的综合结果。
